PMID: 8962049Dec 10, 1996Paper

Nature knows best: an amazing reaction cascade is uncovered by design and discovery

Proceedings of the National Academy of Sciences of the United States of America
C H Heathcock

Abstract

The Daphniphyllum alkaloids are a group of highly complex polycyclic alkaloids. Examination of the structures if several members of this family of natural products led to a hypothesis about their mode of biosynthesis (depicted in Scheme I). Based on this hypothetical biosynthetic pathway, a laboratory synthesis was designed that incorporated as a key transformation the novel one-pot transformation of dialdehyde 24 to pentacyclic unsaturated amine 25. This process turned out to be an exceptionally efficient way to construct the pentacyclic nucleus of the Daphniphyllum alkaloids. However, a purely fortuitous discovery, resulting from accidental use of methylamine rather than ammonia, led to a great improvement in the synthesis and suggests an even more attractive possible biosynthesis.

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Jul 3, 2003·Bioorganic & Medicinal Chemistry·Erik J Sorensen
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