PMID: 7539608Jun 1, 1995Paper

Nature of coarctation in hypoplastic left heart syndrome

The Annals of Thoracic Surgery
M Machii, A E Becker

Abstract

The study was designed to establish the underlying pathology of aortic coarctation in hypoplastic left heart syndrome. Aortic coarctation in patients with hypoplastic left heart syndrome is a significant problem when a Norwood procedure or heart transplantation is performed. Previous reports have claimed that the obstruction was merely a branch-point phenomenon and that ductal tissue was absent. Five heart specimens with hypoplastic left heart syndrome and aortic coarctation were examined histologically. The distal segment of the aortic arch, together with the arterial duct, were dissected and processed en bloc. The blocks were sectioned parallel to the longitudinal axis of the aortic arch. In 4 hearts the coarctation was in the preductal position. Ductal tissue encircled the aortic lumen and extended into the aorta both proximally and distally from the ductal orifice. The fifth case showed medial thickening of the aortic wall in the preductal position, but without ductal tissue. The arterial duct showed histologic characteristics of persistent patency. Our observations suggest that aortic coarctation in the preductal position in hypoplastic left heart syndrome is caused by the extension of ductal tissue. The findings may have ...Continue Reading

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Citations

Aug 26, 1998·Journal of the American College of Cardiology·G S ShiraliR L Larsen
Dec 7, 2013·General Thoracic and Cardiovascular Surgery·Yorikazu Harada
Jun 8, 2014·The Annals of Thoracic Surgery·Chiara CorsiniUNKNOWN MOCHA Collaborative Group
Jul 23, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Masataka KitanoKoji Kagisaki
Oct 16, 2015·Current Treatment Options in Cardiovascular Medicine·Anjori BhatiaJeffrey T Kuvin
Jan 10, 2006·The Journal of Thoracic and Cardiovascular Surgery·Emile A BachaZiyad M Hijazi
Jul 18, 2015·The Journal of Thoracic and Cardiovascular Surgery·Holly E M MewhortChristopher Caldarone
Jul 7, 2005·The Journal of Thoracic and Cardiovascular Surgery·Harold M BurkhartGlen S Van Arsdell
Mar 22, 2008·The Annals of Thoracic Surgery·Traci M AshcraftPeter B Manning
Aug 2, 2000·The Annals of Thoracic Surgery·I ShiraishiK Hamaoka
May 4, 2016·The Annals of Thoracic Surgery·Sunita J FernsMichel N Ilbawi
May 18, 2000·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·W TworetzkyP Moore
Aug 22, 2014·Current Treatment Options in Cardiovascular Medicine·Mohammed Haris Umer UsmanChristian Witzke-Sanz

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Aortic coarctation is a congenital condition characterized by narrowing of the aorta. Discover the latest research on this disease here.