PMID: 46753Jan 1, 1975

Nature of cold-reactive antibodies to lymphocyte surface determinants in systemic lupus erythematosus

Arthritis and Rheumatism
J B WinfieldH G Kunkel


Antilymphocyte antibodies in serum from patients with systemic lupus erythematosus (SLE), as detected by microcytotoxicity and indirect immunofluorescence, were predominantly cold reactive and of the IgM class. These IgM antibodies were most active at 4 degrees C. IgG antibodies were infrequent, and were only minimally lymphocytotoxic. Most sera were cytotoxic for autologous lymphocytes and were equally reactive with normal and SLE lymphocytes, as well as with B- and T-cell preparations. Separate T- and B-cell specificities, which appeared not to be related to HL-A determinants, were identified by differential absorption experiments. The functional significance of these antilymphocyte antibodies is discussed.


Jan 1, 1976·Arthritis and Rheumatism·P D Utsinger
May 1, 1976·Arthritis and Rheumatism·S R BlockC L Christian
Nov 11, 1976·Arthritis and Rheumatism·R C WilliamsJ D Montaño
Jun 1, 1977·Arthritis and Rheumatism·W P ArendG A Starkebaum
Jun 1, 1978·Arthritis and Rheumatism·R C Williams, A D Bankhurst
Jun 1, 1978·Arthritis and Rheumatism·J B WinfieldA Singer
Jan 1, 1979·Arthritis and Rheumatism·M E Hamilton, J B Winfield
Oct 1, 1979·Arthritis and Rheumatism·A L Schocket, P F Kohler
Jan 1, 1984·Medical Microbiology and Immunology·T EbinaM Ohta
Dec 7, 1975·The New England Journal of Medicine·S J KorsmeyerR G Strickland
Sep 15, 1977·The New England Journal of Medicine·W Pruzanski, K H Shumak
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·H G Bluestein
Dec 1, 1990·The Journal of Experimental Medicine·W JarjourJ B Winfield
Jun 1, 1976·Scandinavian Journal of Immunology·R J Winchester, S M Fu
Apr 1, 1977·Australian and New Zealand Journal of Medicine·S Whittingham, I R Mackay
Jan 1, 1978·Australian and New Zealand Journal of Medicine·R L DawkinsP J Zilko
Oct 1, 1975·Annals of the Rheumatic Diseases·T MoritoT Juji
Jan 1, 1979·Journal of Clinical Pathology. Supplement (Royal College of Pathologists)·B BresnihanG R Hughes
Jan 1, 1976·The Journal of Clinical Investigation·A N TheofilopoulosF J Dixon
Feb 1, 1976·The Journal of Clinical Investigation·J D StoboP E Hermans
Feb 1, 1976·The Journal of Clinical Investigation·H G Bluestein, N J Zvaifler
Oct 1, 1977·The Journal of Clinical Investigation·S StagnoC A Alford
Jan 1, 1982·The Journal of Clinical Investigation·K OkudairaR C Williams
Apr 1, 1982·The Journal of Clinical Investigation·K OkudairaR C Williams
Mar 1, 1984·The Journal of Clinical Investigation·C MorimotoS F Schlossman


Jun 12, 1971·Lancet·J F Jennings
Jun 12, 1971·Lancet·P Stastny, M Ziff
Jul 1, 1973·Clinical Immunology and Immunopathology·Z BentwichH G Kunkel
Dec 1, 1973·The Journal of Clinical Investigation·R P MessnerR C Williams
Feb 1, 1974·The Journal of Experimental Medicine·S M FuH G Kunkel
Mar 15, 1974·Cellular Immunology·I O AuerF Milgrom
Jul 1, 1971·The Journal of Clinical Investigation·R C WilliamsE J Yunis
Jul 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·T Shirai, R C Mellors
Oct 1, 1970·The New England Journal of Medicine·P I TERASAKIE V Barnett
Mar 28, 1970·Nature·K K MittalW T Butler
Nov 1, 1970·Transplantation·M J KreislerP I TERASAKI
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen
Dec 5, 1964·Nature·C H VANGRAAN, C H WYNDHAM

Related Concepts

Immunofluorescence Assay
Cold Temperature
Antigenic Specificity
Lymphoid Cells
Dall Sheep
Immunofluorescence Microscopy
Chemical Fractionation

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.