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Nature of the calcium dependent potassium leak induced by (+)-propranolol, and its possible relevance to the drug's antiarrhythmic effect

British Journal of Pharmacology

Feb 1, 1972

Ian M Glynn, Adam Warner

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Abstract

1. Manninen (1970) recently reported that in the presence of calcium ions, (+)-propranolol causes a massive loss of potassium ions from human red cells, together with a marked inward ;counter-transport' of potassium ions from the medium.2. This paper shows, theoretically, that counter-t...read more

Mentioned in this Paper

Potassium
Plasma Membrane
Propranolol
Mathematics
Calcium [EPC]
Protein S
Potassium Measurement
Cell Membrane Permeability
Cardiac Depressants
Diffusion
Paper Details
References
  • References19
  • Citations18
12

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Nature of the calcium dependent potassium leak induced by (+)-propranolol, and its possible relevance to the drug's antiarrhythmic effect

British Journal of Pharmacology

Feb 1, 1972

Ian M Glynn, Adam Warner

PMID: 4668594

DOI: 10.1111/j.1476-5381.1972.tb07263.x

Abstract

1. Manninen (1970) recently reported that in the presence of calcium ions, (+)-propranolol causes a massive loss of potassium ions from human red cells, together with a marked inward ;counter-transport' of potassium ions from the medium.2. This paper shows, theoretically, that counter-t...read more

Mentioned in this Paper

Potassium
Plasma Membrane
Propranolol
Mathematics
Calcium [EPC]

Related Papers

Paper Details
References
  • References19
  • Citations18
12

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