PMID: 7010008Sep 1, 1980Paper

Nature of the decline in antigen-induced humoral immunity with age

Mechanisms of Ageing and Development
T Makinodan

Abstract

An attempt has been made to summarize our present knowledge of the influence of age on humoral immunity, as judged by the ability of an individual to generate antibody in response to antigenic stimulation. In general, humoral immunity declines with age, and the onset can occur as early as when an individual reaches sexual maturity. The decline is due to changes in the immune cells and their milieu. Cell loss, shift in the proportion of subpopulations, and qualitative cellular changes have all been detected. The most prominent cellular target of aging appears to be T cells involved in the regulation of humoral response. Since the changes are closely associated with the involution and atrophy of the thymus, an understanding of its changes could be the key to understanding immunosenescence.

References

Jan 1, 1978·Mechanisms of Ageing and Development·A M PreumontJ Brachet
Apr 1, 1978·Mechanisms of Ageing and Development·C F Tam, R L Walford
Feb 1, 1978·Mechanisms of Ageing and Development·K Hirokawa, T Sado
Feb 1, 1977·Cellular Immunology·C CarnaudJ F Bach
Apr 1, 1979·Mechanisms of Ageing and Development·B RivnayM Shinitzky
Jul 11, 1973·Nature: New Biology·L Olsson, M H Claësson
May 1, 1974·Cellular Immunology·E D CarosellaM Braun
Jul 8, 1972·Life Sciences. Pt. 2: Biochemistry, General and Molecular Biology·Y H O, R A Conard
Jan 1, 1974·The Journal of Clinical Investigation·M E Weksler, T H Hütteroth
Dec 1, 1971·Transplantation·M F Jeejeebhoy
Jun 1, 1966·Journal of Cellular Physiology·J F Albright, T Makinodan

❮ Previous
Next ❯

Citations

Apr 6, 2012·Immunologic Research·Paulina Dominika RymkiewiczAnis Larbi
Jul 1, 1983·Mechanisms of Ageing and Development·M A Hollingsworth, D L Evans
Dec 4, 2003·Biological & Pharmaceutical Bulletin·Alice Lok Sze HoHsiao Chang Chan
Jan 1, 1983·Journal of the American Geriatrics Society·T T Yoshikawa
Aug 27, 2013·PloS One·Bérangère DelegliseJean-Michel Peyrin
Apr 3, 2014·PLoS Biology·Athanasios MetaxakisLinda Partridge
Mar 1, 2012·PloS One·Guangliang CaoDengshun Miao
Oct 8, 2013·PloS One·Małgorzata MarjańskaMelissa Terpstra
Aug 7, 2020·Seminars in Immunopathology·Graham Pawelec
Dec 16, 2019·Ageing Research Reviews·Antero Salminen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.