PMID: 4292638Jan 1, 1967Paper

Nature of the pressor substance in rabbit placenta

The Biochemical Journal
M ZieglerF Gross

Abstract

1. The renin-like substance isolated from the placenta of the rabbit produces a prolonged increase of blood pressure in the nephrectomized rat. If incubated with renin substrate from ox serum, it forms a pressor substance that elevates blood pressure in exactly the same way as does angiotensin. 2. This angiotensin-like principle was concentrated by means of ion-exchange chromatography and compared with Val-5-angiotensins I and II in two paper-chromatography systems and in paper electrophoresis. 3. In all the three methods the unknown principle behaved like a mixture of the two reference compounds. 4. It is concluded that incubation of the renin-like substance of placental origin with substrate from ox serum gave a mixture of Val-5-angiotensins I and II. This is evidence that the enzyme isolated from the placenta is either closely related to, or identical with, renin.

Citations

Jun 1, 1969·Archives of Biochemistry and Biophysics·J B Mudd, T T McManus
Sep 1, 1968·Klinische Wochenschrift·J Limberger, M Ziegler
Apr 1, 1969·Acta Medica Scandinavica·G Morandini, C Mangioni

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