Nature of the renal concentrating defect in sickle cell disease

The Journal of Clinical Investigation
F E HatchL W DIGGS

Abstract

Free water reabsorption (T(c) (H2O)) measured during 10% mannitol diuresis and subsequently during 3% saline diuresis was compared in patients with sickle cell anemia and in normal subjects. During mannitol infusion, T(c) (H2O) progressively rose with increasing osmolar clearance (C(osm)) and reached a maximal level in both groups studied. During hypertonic saline diuresis, T(c) (H2O) progressively rose in the normal subjects and exceeded the maximal levels attained during mannitol diuresis, with no evidence of a maximal T(c) (H2O) level appearing. In contrast, none of the saline curves significantly exceeded the mannitol curves in the sickle cell patients but tended to parallel the mannitol curves at comparable rates of solute clearance. Since T(c) (H2O) is an index of both solute (sodium) transport from the loop of Henle and solute accumulation in the hypertonic medullary interstitium, tubular sodium handling was examined in both sickle cell patients and control subjects alike. No difference in the tubular transport of sodium could be demonstrated either under conditions of sodium loading or under conditions in which the tubular sodium load was low (water diuresis). These data support the conclusion that the defect in urinary...Continue Reading

References

Jul 1, 1954·The Journal of Clinical Investigation·G A ZAKH W SMITH
Feb 1, 1955·The American Journal of Medicine·J N ETTELDORFL W DIGGS
Oct 1, 1955·The Journal of Clinical Investigation·M WALSERJ ORLOFF
Sep 1, 1956·The Journal of Clinical Investigation·H A ITANOD THOMPSON
Oct 1, 1957·The Journal of Clinical Investigation·R W BERLINER, D G DAVIDSON
Oct 1, 1960·The American Journal of Medicine·M F LEVITTD POLIMEROS
Apr 1, 1963·The Journal of Clinical Investigation·P E PERILLIE, F H EPSTEIN
May 1, 1964·The American Journal of Medicine·G GIEBISCH, E E WINDHAGER
May 1, 1964·The American Journal of Medicine·C W GOTTSCHALK
Feb 1, 1965·The Journal of Clinical Investigation·M GOLDBERGM A RAMIREZ
Jul 1, 1965·Archives of Internal Medicine·F E HATCH, L W DIGGS

❮ Previous
Next ❯

Citations

Mar 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·L W Statius van EpsL W La Porte-Wijsman
Jul 21, 2001·The New England Journal of Medicine·L S KingP Agre
Oct 12, 2013·Néphrologie & thérapeutique·Maud CazenaveVincent Audard
Sep 1, 1986·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·C J Kelly, I Singer
Nov 19, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sara Combs, Tomas Berl
Feb 1, 1989·Kidney International·P A GabowR W Schrier
Jun 1, 1975·Kidney International·G A Alleyne
Sep 10, 2011·British Journal of Haematology·Claire C Sharpe, Swee L Thein
Dec 18, 2013·British Journal of Haematology·Santosh L SarafVictor R Gordeuk
Feb 1, 1982·The American Journal of Medicine·D BatlleN A Kurtzman
Feb 1, 1982·The American Journal of Medicine·R L Jamison, R E Oliver
Jun 1, 1978·The Journal of Pediatrics·B B Sellers
Dec 1, 1976·The Journal of Pediatrics·R A DeFronzoH A Pearson
Aug 1, 1979·The Journal of Pediatrics·M C MatustikW J Meyer
May 1, 1976·The Journal of Pediatrics·E G RadelL Finberg
Jun 22, 2016·Advances in Chronic Kidney Disease·Sana KhanMitchell H Rosner
May 10, 2005·The Journal of Urology·Lijo SimpsonRaymond C Bergan
May 11, 2010·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·W Douira-KhomsiI Bellagha
Jan 1, 1974·Acta paediatrica Scandinavica·O H OetlikerH U Tietze
Jan 1, 1982·Journal of the American College of Nutrition·M C MatustikW J Meyer
Mar 1, 1984·Annals of Tropical Paediatrics·J M HamdanM S Ahmad
May 8, 1999·Journal of the American Society of Nephrology : JASN·A GuaschL J Elsas
Mar 1, 1997·Kidney International·A GuaschW E Mitch
May 1, 1985·Kidney International·P E de Jong, L W Statius van Eps

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Clinica Chimica Acta; International Journal of Clinical Chemistry
L W Statius van EpsA M Struyker Boudier
The Journal of Clinical Investigation
H A ITANOD THOMPSON
Clinica Chimica Acta; International Journal of Clinical Chemistry
J P GoossensA L Giterson
The American Journal of Medicine
M F LEVITTD POLIMEROS
© 2021 Meta ULC. All rights reserved