Nausea and vomiting in children and adolescents receiving intrathecal methotrexate: A prospective, observational study

Pediatric Blood & Cancer
J FlankL L Dupuis

Abstract

The prevalence of nausea and vomiting after receipt of intrathecal methotrexate (IT-MTX) in pediatric oncology patients is unknown. Patients (4-18 years) about to receive IT-MTX were eligible to participate in this prospective, observational study. Patients received antiemetics as prescribed by their clinical team. Nausea severity (patient-assessed), timing of emetic episodes, and administration of antiemetics were recorded beginning immediately prior to IT-MTX administration, for the next 24 hr (acute phase), and for a maximum of 7 additional days (delayed phase). Complete chemotherapy-induced nausea and vomiting (CINV) control was defined as no emetic episodes and no nausea. One hundred patients consented to participate in this study; 70 provided evaluable data (mean age: 8.3 years; range: 4.1-17.6). Most (94%) received propofol-containing anesthesia for IT-MTX administration. Most (89%) received a 5-HT3 antagonist prior to IT-MTX. During the acute phase, 36 children (51%) experienced complete CINV control, 67 (96%) complete vomiting control, and 36 (51%) complete nausea control. Severe acute phase nausea was reported by 12 children (17%). During the delayed phase, 35 patients (50%) experienced complete CINV control, 60 (86%)...Continue Reading

References

Apr 16, 1998·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·M T HoldsworthC M Chavez
Jul 24, 2008·Pediatric Blood & Cancer·Kim NagelRonald D Barr
Apr 6, 2011·Pediatric Blood & Cancer·L Lee DupuisUNKNOWN Pediatric Oncology Group of Ontario
Mar 21, 2013·Pediatric Blood & Cancer·L Lee DupuisUNKNOWN Pediatric Oncology Group of Ontario
Dec 21, 2013·Anesthesia and Analgesia·Tong J GanUNKNOWN Society for Ambulatory Anesthesia

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Citations

Dec 24, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Krista McKinnon, Jennifer Jupp
Jul 17, 2019·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Mary C Hooke, Lauri A Linder
Aug 1, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Alexandra M WalshVinay Vadiya
Jan 25, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Melissa BeaucheminRebecca Schnall
Aug 28, 2020·Journal of Child and Adolescent Psychopharmacology·Orit PeledNoa Benaroya-Milshtein
Jun 1, 2017·Pediatric Blood & Cancer·Melanie Brooke Bernhardt

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