NaV 1.9 channels in muscle afferent neurons and axons

Journal of Neurophysiology
Tyler L MarlerKeith S Elmslie

Abstract

The exercise pressor reflex (EPR) is activated by muscle contractions to increase heart rate and blood pressure during exercise. While this reflex is beneficial in healthy individuals, the reflex activity is exaggerated in patients with cardiovascular disease, which is associated with increased mortality. Group III and IV afferents mediate the EPR and have been shown to express both tetrodotoxin-sensitive (TTX-S, NaV1.6, and NaV1.7) and -resistant (TTX-R, NaV1.8, and NaV1.9) voltage-gated sodium (NaV) channels, but NaV1.9 current has not yet been demonstrated. Using a F--containing internal solution, we found a NaV current in muscle afferent neurons that activates at around -70 mV with slow activation and inactivation kinetics, as expected from NaV1.9 current. However, this current ran down with time, which resulted, at least in part, from increased steady-state inactivation since it was slowed by both holding potential hyperpolarization and a depolarized shift of the gating properties. We further show that, following NaV1.9 current rundown (internal F-), application of the NaV1.8 channel blocker A803467 inhibited significantly more TTX-R current than we had previously observed (internal Cl-), which suggests that NaV1.9 current...Continue Reading

References

May 1, 1985·The Journal of General Physiology·P Forscher, G S Oxford
Sep 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M P KaufmanG A Ordway
Jul 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M P KaufmanJ H Mitchell
Jun 1, 1993·Pflügers Archiv : European journal of physiology·K S ElmslieS W Jones
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·S D Dib-HajjS G Waxman
Apr 26, 2002·Trends in Neurosciences·Sulayman Dib-HajjStephen G Waxman
Jul 26, 2002·Experimental Eye Research·Joel A Black, Stephen G Waxman
Apr 6, 2004·Exercise and Sport Sciences Reviews·Mary E J Lott, Lawrence I Sinoway
May 4, 2004·Molecular and Cellular Neurosciences·Bertrand CostePatrick Delmas
Aug 4, 2004·Pflügers Archiv : European journal of physiology·Hiroshi MaruyamaNobukuni Ogata
Jun 1, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Huai-Zhen RuanGeoffrey Burnstock
Jun 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Birgit T PriestWilliam J Martin
Jun 28, 2005·Pflügers Archiv : European journal of physiology·Andreas LefflerTheodore R Cummins
Nov 12, 2005·Experimental Physiology·Scott A SmithMary G Garry
Jul 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xin FangSally N Lawson
Dec 13, 2006·The Journal of Physiology·Anthony M RushStephen G Waxman
Dec 15, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fumimasa AmayaClifford J Woolf
May 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael F JarvisDouglas S Krafte
Feb 14, 2008·The Journal of General Physiology·François MaingretPatrick Delmas
Sep 8, 2010·Molecular and Cellular Neurosciences·Cojen Ho, Michael E O'Leary
Nov 3, 2010·The Journal of Physiology·Han-Jun WangWei Wang
Jul 30, 2011·Exercise and Sport Sciences Reviews·Mary G Garry
Aug 16, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Megan N MurphyScott A Smith
Nov 8, 2011·Experimental Physiology·Marc P Kaufman
Aug 3, 2012·Journal of Neurophysiology·Renuka RamachandraKeith S Elmslie
Oct 13, 2012·Frontiers in Physiology·Han-Jun WangWei Wang
Jan 30, 2013·The Journal of General Physiology·Carlos G VanoyeAlfred L George
Jul 12, 2013·Journal of Neurophysiology·Renuka RamachandraKeith S Elmslie
Aug 24, 2013·Journal of Applied Physiology·Matthew D MullerLawrence I Sinoway
Oct 29, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Jody L GreaneyWilliam B Farquhar
May 23, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhi-Yong TanTheodore R Cummins
Jun 27, 2014·Journal of Neurophysiology·James C BaxterKeith S Elmslie
Dec 3, 2014·Autonomic Neuroscience : Basic & Clinical·Audrey J Stone, Marc P Kaufman
Apr 10, 2015·Journal of Neurophysiology·Audrey J StoneMarc P Kaufman
Sep 6, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Marty D SprangerScott A Smith

❮ Previous
Next ❯

Citations

Feb 27, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Qin LiJianhua Li
Nov 12, 2021·Frontiers in Neuroscience·Rikki K QuinnRebecca Lim

❮ Previous
Next ❯

Software Mentioned

Igor Pro
S5
ImageJ

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.