Navigated transcranial magnetic stimulation does not decrease the variability of motor-evoked potentials

Brain Stimulation
Nikolai H JungVolker Mall

Abstract

One major attribute of transcranial magnetic stimulation (TMS) is the variability of motor-evoked potential (MEP) amplitudes, to which variations of coil positioning may contribute. Navigated TMS allows the investigator to retrieve a stimulation site with an accuracy of 2.5 mm and to retain coil position with low spatial divergence during stimulation. The purpose of this study was to investigate whether increased spatial constancy of the coil using a navigational system decreases the variability of MEP amplitudes and increases their reproducibility between different points in time of investigation. We investigated eight healthy subjects (mean age 23.8 +/- 1.2 years, range 22-25, four women, four men) at three different points in time with and without an optically tracked frameless navigational device, respectively. Input-output curves, motor threshold, and MEP amplitudes were recorded. We calculated the coefficient of variation as statistical parameter of variability. Reproducibility between different sessions was assessed via the MEP amplitude. The coefficient of variance of MEP amplitudes did not show a distinct difference between navigated and non-navigated TMS in input-output curves. MEP amplitudes, indicating reproducibili...Continue Reading

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Citations

Jun 15, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Florian MainbergerVolker Mall
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