Navigating life

Hippocampus
Neal J Cohen

Abstract

The discoveries of "place cells" in the hippocampus and "grid cells" in the entorhinal cortex are landmark achievements in relating behavior to neural activity, permitting analysis of a powerful system for spatial representation in the brain. The contributions of this work include not only the empirical findings but also the approach this work pioneered of examining neural activity in complex behaviors with real ecological validity in freely moving animals, and of attempting to place the findings in the larger context of how the neural representations of space are used in service of real-world behavior, namely what the Nobel committee described as permitting us to "navigate our way through a complex environment." These discoveries and approaches have had far-ranging impact on and implications for work in human cognitive neuroscience, where we see (1) confirmation in humans that the hippocampus and overlying MTL cortex are critically engaged in supporting a relational representation of space, and that it can be used for flexible spatial navigation and (2) evidence that these regions are also critically involved in aspects of relational memory not limited to space, and in the flexible use of hippocampal memory extending beyond sp...Continue Reading

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Citations

Jun 4, 2016·Hippocampus·Maria C D'AngeloJennifer D Ryan
Jul 12, 2016·Hippocampus·Howard EichenbaumMenno Witter
Jul 20, 2017·Memory & Cognition·Maria C D'AngeloJennifer D Ryan
Feb 15, 2019·Frontiers in Psychology·Giovanni Berlucchi, Carlo Alberto Marzi
Apr 20, 2018·Brain Structure & Function·Catarina Rendeiro, Justin S Rhodes
Mar 14, 2020·Network Neuroscience·Jennifer D RyanAnthony R McIntosh

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