Navigation of brain networks

Proceedings of the National Academy of Sciences of the United States of America
Caio SeguinAndrew Zalesky

Abstract

Understanding the mechanisms of neural communication in large-scale brain networks remains a major goal in neuroscience. We investigated whether navigation is a parsimonious routing model for connectomics. Navigating a network involves progressing to the next node that is closest in distance to a desired destination. We developed a measure to quantify navigation efficiency and found that connectomes in a range of mammalian species (human, mouse, and macaque) can be successfully navigated with near-optimal efficiency (>80% of optimal efficiency for typical connection densities). Rewiring network topology or repositioning network nodes resulted in 45-60% reductions in navigation performance. We found that the human connectome cannot be progressively randomized or clusterized to result in topologies with substantially improved navigation performance (>5%), suggesting a topological balance between regularity and randomness that is conducive to efficient navigation. Navigation was also found to (i) promote a resource-efficient distribution of the information traffic load, potentially relieving communication bottlenecks, and (ii) explain significant variation in functional connectivity. Unlike commonly studied communication strategie...Continue Reading

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Citations

Jan 12, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alessandro Muscoloni, Carlo Vittorio Cannistraci
Jan 12, 2019·Proceedings of the National Academy of Sciences of the United States of America·Caio SeguinAndrew Zalesky
May 10, 2018·Proceedings of the National Academy of Sciences of the United States of America·Richard F Betzel, Danielle S Bassett
Feb 7, 2020·Human Brain Mapping·Ioannis PappasEmmanuel A Stamatakis
Apr 23, 2020·Journal of the Royal Society, Interface·Salva Duran-NebredaGeorge W Bassel
Oct 23, 2019·Network Neuroscience·Xin WangRaymond Kai-Yu Tong
Apr 13, 2019·Scientific Reports·Hunki KwonJong-Min Lee
Aug 8, 2020·Proceedings of the National Academy of Sciences of the United States of America·Muhua ZhengM Ángeles Serrano
Aug 6, 2019·Frontiers in Neural Circuits·Aurina ArnatkevičiūtėAlex Fornito
Oct 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Bertha Vázquez-RodríguezBratislav Misic
Sep 22, 2020·Brain Communications·Bastian ChengGötz Thomalla
Sep 21, 2019·Nature Communications·Caio SeguinAndrew Zalesky
Feb 6, 2020·PLoS Computational Biology·Antoine Allard, M Ángeles Serrano
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Nov 17, 2020·Network Neuroscience·Eufemia Lella, Ernesto Estrada
Nov 17, 2020·Network Neuroscience·Bertha Vézquez-RodríguezBratislav Misic
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Mar 12, 2021·Brain Structure & Function·Phoebe ImmsKaren Caeyenberghs
Jul 6, 2021·Frontiers in Neuroscience·Reza Rastmanesh, Matti Pitkänen
Jul 10, 2021·ELife·Pierpaolo SorrentinoAndrew Zalesky
Aug 15, 2021·Brain Structure & Function·Matteo ManciniSusie Y Huang
Feb 19, 2020·NeuroImage·Tabinda SarwarAndrew Zalesky

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