Nb-C nanocomposite films with enhanced biocompatibility and mechanical properties for hard-tissue implant applications

ACS Applied Materials & Interfaces
Luis YateGuocheng Wang

Abstract

One of the key challenges in engineering of orthopedic implants is to "bioactivate" their surface by using different surface techniques and materials. Carbon, especially amorphous (a-C) and diamond-like carbon down (DLC) films have attracted much attention in biomedical fields due to their biocompatibility and low coefficient of friction. However, they are unsuitable for uses as a "bioactivity enhancer" of orthopedic implants due to their bioinertness. In this work, we use the nonreactive magnetron sputtering technique to produce a-C films including the biocompatible niobium (Nb) element to alter the surface chemistry and nanotopography of the a-C films with the purpose of bioactivating the a-C film coated implants. Results show that the nanocomposite films (Nb-C) formed by the addition of Nb into the a-C films not only have improved corrosion resistance, but also possess enhanced mechanical properties (nanohardness, Young's modulus and superelastic recovery). Preosteoblasts (MC3T3-E1) cultured on the Nb-C films have enhanced adhesion and upregulated alkaline phosphatase (ALP) activity, compared to those cultured on the a-C film and TiO2 films used as a control, which are thought to be ascribed to the combined effects of the ch...Continue Reading

References

Feb 13, 2001·Clinical Orthodontics and Research·M DalstraB Melsen
Jan 30, 2008·Acta Biomaterialia·S VirtanenY T Konttinen
Aug 13, 2008·Tissue Engineering. Part a·Jason A Burdick, Gordana Vunjak-Novakovic
Jul 25, 2009·Journal of the Mechanical Behavior of Biomedical Materials·L E MurrR B Wicker
Feb 2, 2010·Trends in Biotechnology·David M Dohan EhrenfestTomas Albrektsson
Jun 28, 2012·Nanomedicine·Naside Gozde Durmus, Thomas J Webster
Jan 26, 2013·Journal of Biomedical Materials Research. Part a·V S A ChallaR D K Misra
May 21, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guocheng WangHala Zreiqat

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Citations

Mar 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Danijela GregurecSergio Enrique Moya
May 24, 2018·Biointerphases·Subramanian BA Bendavid

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