NB-LRR signaling induces translational repression of viral transcripts and the formation of RNA processing bodies through mechanisms differing from those activated by UV stress and RNAi

Journal of Experimental Botany
Louis-Valentin MeteignierPeter Moffett

Abstract

Plant NB-LRR proteins confer resistance to multiple pathogens, including viruses. Although the recognition of viruses by NB-LRR proteins is highly specific, previous studies have suggested that NB-LRR activation results in a response that targets all viruses in the infected cell. Using an inducible system to activate NB-LRR defenses, we find that NB-LRR signaling does not result in the degradation of viral transcripts, but rather prevents them from associating with ribosomes and translating their genetic material. This indicates that defense against viruses involves the repression of viral RNA translation. This repression is specific to viral transcripts and does not involve a global shutdown of host cell translation. As a consequence of the repression of viral RNA translation, NB-LRR responses induce a dramatic increase in the biogenesis of RNA processing bodies (PBs). We demonstrate that other pathways that induce translational repression, such as UV irradiation and RNAi, also induce PBs. However, by investigating the phosphorylation status of eIF2α and by using suppressors of RNAi we show that the mechanisms leading to PB induction by NB-LRR signaling are different from these stimuli, thus defining a distinct type of transla...Continue Reading

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Citations

Jan 10, 2018·Frontiers in Plant Science·Kristiina MäkinenMaija Pollari
Nov 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Jérémie BazinJulia Bailey-Serres
Apr 4, 2019·Molecular Plant Pathology·Annette Niehl, Manfred Heinlein
Aug 16, 2019·Molecular Plant-microbe Interactions : MPMI·Min XuRichard Kormelink
Jul 16, 2019·Journal of Experimental Botany·Vardis Ntoukakis, Miriam L Gifford
Mar 19, 2019·Journal of Experimental Botany·Aayushi ShuklaAnders Hafrén
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Jul 31, 2019·Plant Phenomics : a Science Partner Journal·Tahani AlkhudaydiBeatriz de la Iglesia
Sep 12, 2020·Molecular Plant·Jie ZhangXinnian Dong
Feb 2, 2021·The Plant Journal : for Cell and Molecular Biology·Manon M S RichardFrank L W Takken
Apr 24, 2021·Frontiers in Plant Science·Brian T RossMichelle L Flenniken

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