NBS1 is required for macrophage homeostasis and functional activity in mice.

Blood
Selma Pereira-LopesAntonio Celada

Abstract

Nijmegen breakage syndrome 1 (NBS1) is a component of the MRE11 complex, which is a sensor of DNA double-strand breaks and plays a crucial role in the DNA damage response. Because activated macrophages produce large amounts of reactive oxygen species (ROS) that can cause DNA lesions, we examined the role of NBS1 in macrophage functional activity. Proliferative and proinflammatory (interferon gamma [IFN-γ] and lipopolysaccharide [LPS]) stimuli led to increased NBS1 levels in macrophages. In mice expressing a hypomorphic allele of Nbs1, Nbs1(∆B/∆B), macrophage activation-induced ROS caused increased levels of DNA damage that were associated with defects in proliferation, delayed differentiation, and increased senescence. Furthermore, upon stimulation, Nbs1(∆B/∆B) macrophages exhibited increased expression of proinflammatory cytokines. In the in vivo 2,4-dinitrofluorobenzene model of inflammation, Nbs1(∆B/∆B) animals showed increased weight and ear thickness. By using the sterile inflammation by zymosan injection, we found that macrophage proliferation was drastically decreased in the peritoneal cavity of Nbs1(∆B/∆B) mice. Our findings show that NBS1 is crucial for macrophage function during normal aging. These results have implic...Continue Reading

References

Oct 1, 1992·The Journal of Experimental Medicine·M K CollinsA Lopez-Rivas
Jul 1, 1996·The Journal of Experimental Medicine·A CeladaR A Maki
Feb 22, 2001·The Journal of Clinical Investigation·C HerreroA Celada
Oct 27, 2001·Molecular Aspects of Medicine·H J Forman, M Torres
Mar 22, 2002·Nature Reviews. Immunology·R Medzhitov
Apr 23, 2002·Current Biology : CB·Bret R WilliamsJohn H J Petrini
Nov 26, 2003·Mutation Research·Geir SlupphaugHans E Krokan
Mar 17, 2004·Molecular and Cellular Biology·Harry A RogoffTimothy F Kowalik
Apr 6, 2004·Developmental and Comparative Immunology·Daniel R BarredaMiodrag Belosevic
Jan 6, 2006·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Maureen R Gwinn, Val Vallyathan
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrée YeramianAntonio Celada
Feb 3, 2007·The Journal of Investigative Dermatology·Marlene BonnevilleAna Hennino
May 9, 2007·The Journal of Experimental Medicine·Simone DifilippantonioAndré Nussenzweig
Jul 11, 2008·Molecular Cell·Travis H StrackerJohn H J Petrini
Jul 17, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carlos SebastiánAntonio Celada
Jul 28, 2009·Nature·Yibin DengSandy Chang
Oct 23, 2009·Nature·Stephen P Jackson, Jiri Bartek
Nov 9, 2010·Genome Integrity·Toshiyuki BohgakiRazqallah Hakem
Nov 9, 2010·Advances in Immunology·Annabel F ValledorAntonio Celada
Jan 22, 2011·Nature Reviews. Molecular Cell Biology·Travis H Stracker, John H J Petrini
Dec 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Martina BauerBernd Kaina
Feb 23, 2012·Cancer Letters·Brian R Berquist, David M Wilson
Mar 2, 2012·The Journal of Clinical Investigation·Antonio Sica, Alberto Mantovani
Aug 2, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Barbara PiątosaEwa Bernatowska
Aug 24, 2012·Nature Reviews. Molecular Cell Biology·Tobias SperkaK Lenhard Rudolph
Aug 28, 2012·Molecular Cell·J Ross ChapmanSimon J Boulton
Feb 8, 2013·Proceedings of the National Academy of Sciences of the United States of America·Takeshi KondoTaro Kawai
Aug 6, 2013·Annual Review of Genetics·Andrés Aguilera, Tatiana García-Muse
Nov 13, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Selma Pereira-LopesAntonio Celada
Apr 30, 2014·Nature Immunology·Susanne RothJürgen Ruland
Jul 19, 2014·Nature Reviews. Immunology·Martin GuilliamsSimon Yona
Dec 3, 2014·Experimental Cell Research·Katrin Rein, Travis H Stracker
Mar 4, 2015·Journal of Clinical Immunology·Gillian I RiceYanick J Crow

❮ Previous
Next ❯

Citations

Dec 26, 2015·Blood·Jeffrey J Bednarski
Mar 2, 2016·Biochimica Et Biophysica Acta·Alex LyakhovichLumir Krejci
Oct 28, 2016·The FEBS Journal·Ana Neves-Costa, Luis F Moita
Apr 10, 2020·European Journal of Immunology·Lorena Valverde-EstrellaAntonio Celada
Mar 28, 2018·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Majid Zaki-DizajiAsghar Aghamohammadi
Nov 28, 2015·Blood·Marco Colonna
Mar 16, 2017·Frontiers in Genetics·Polyxeni KalisperatiStavros Sougioultzis
Feb 20, 2019·Nature Reviews. Immunology·Jeffrey J Bednarski, Barry P Sleckman
Dec 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Dale R BalceHerbert W Virgin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.