NCAPG confers trastuzumab resistance via activating SRC/STAT3 signaling pathway in HER2-positive breast cancer.

Cell Death & Disease
Lili JiangLibing Song

Abstract

HER2+ breast cancer (BC) is characterized by rapid growth, early recurrence, early metastasis, and chemoresistance. Trastuzumab is the most effective treatment for HER2+ BC and effectively reduces the risk of recurrence and death of patients. Resistance to trastuzumab results in cancer recurrence and metastasis, leading to poor prognosis of HER2+ BC. In the present study, we found that non-structural maintenance of chromosome condensin 1 complex subunit G (NCAPG) expression was highly upregulated in trastuzumab-resistant HER2+ BC. Ectopic NCAPG was positively correlated with tumor relapse and shorter survival in HER2+ BC patients. Moreover, overexpression of NCAPG promoted, while silencing of NCAPG reduced, the proliferative and anti-apoptotic capacity of HER2+ BC cells both in vitro and in vivo, indicating NCAPG reduces the sensitivity of HER2+ BC cells to trastuzumab and may confer trastuzumab resistance. Furthermore, our results suggest that NCAPG triggers a series of biological cascades by phosphorylating SRC and enhancing nuclear localization and activation of STAT3. To summarize, our study explores a crucial role for NCAPG in trastuzumab resistance and its underlying mechanisms in HER2+ BC, and suggests that NCAPG could b...Continue Reading

References

Aug 30, 2000·Nature·C M PerouD Botstein
Jun 20, 2001·Experimental Cell Research·M A OlayioyeN E Hynes
Apr 3, 2004·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Scott M Dehm, Keith Bonham
Oct 2, 2004·Current Biology : CB·Alfred LammensKarl-Peter Hopfner
Feb 8, 2006·American Journal of Clinical Oncology·Alberto OcañaAtanasio Pandiella
May 16, 2006·Biochemical and Biophysical Research Communications·Lu QianNing Guo
Aug 22, 2006·Current Opinion in Cell Biology·Satyajit K Mitra, David D Schlaepfer
Nov 14, 2006·Breast Cancer Research : BCR·Rita Nahta, Francisco J Esteva
Jan 19, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G ValabregaM Aglietta
Apr 19, 2007·Journal of the National Cancer Institute·Maurizio ScaltritiJosé Baselga
Jul 6, 2007·The New England Journal of Medicine·Clifford A Hudis
Dec 17, 2009·Future Oncology·Kermit L CarrawayCoralie A Carothers Carraway
Dec 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paula R PohlmannRay Mernaugh
Jan 15, 2015·Annual Review of Medicine·Mothaffar F RimawiC Kent Osborne
Jul 24, 2015·JAMA Oncology·Mark M Moasser, Ian E Krop
Mar 2, 2016·Proceedings of the National Academy of Sciences of the United States of America·Saya H EbbesenScott W Lowe
Aug 16, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Fausto PetrelliSandro Barni
Oct 24, 2017·Molecular Cell·Mouhannad MalekLen R Stephens
Mar 1, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Takayuki AraiNaohiko Seki
Dec 6, 2019·OncoTargets and Therapy·Chengwu GongLinquan Wu

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
xenografts
transfection
PCR
flow cytometry
Assay

Software Mentioned

CFX Manager
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.