Nck/Dock: an adapter between cell surface receptors and the actin cytoskeleton

Oncogene
W LiD T Woodley

Abstract

In response to extracellular signals, cell surface receptors engage in connections with multiple intracellular signaling pathways, leading to the cellular responses such as survival, migration, proliferation and differentiation. The 'pY-->SH2/SH3-->effector' connection is a frequently used scheme by many cell surface receptors, in which SH2/SH3-containing adapters connect protein tyrosine phosphorylation to a variety of downstream effector pathways. Following the initial landmark finding that Grb2 adapter links the receptors to the Ras pathway leading to DNA synthesis, recent studies have revealed that the biological function of the SH2/SH3 adapter Nck/Dock is to link cell surface receptors to the actin cytoskeleton. For example, in the evolutionarily-conserved signaling network, GEF-Rac-Nck-Pak, Nck 'fixes up' the interaction of Pak with its upstream activator, Rac. The activated Pak then regulates the cytoskeletal dynamics. The fact that the majority of the more than 20 Nck-SH3-associated effectors are regulators of the actin cytoskeleton suggests that Nck/Dock regulates, via binding to distinct effectors, various cell type-specific motogenic responses. This review focuses on our current understanding of Nck/Dock function. Du...Continue Reading

References

Oct 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B MargolisJ Schlessinger
Dec 15, 1991·The Biochemical Journal·E ManserL Lim
Jan 1, 1991·Annual Review of Medicine·T F DeuelA F Pierce
Feb 16, 1995·Nature·T Pawson
Jan 1, 1995·Annual Review of Medicine·G F Pierce, T A Mustoe
Mar 31, 1995·The Journal of Biological Chemistry·J K JackmanP R Findell
Jan 1, 1994·Progress in Biophysics and Molecular Biology·B Margolis
Aug 1, 1994·Protein Science : a Publication of the Protein Society·W A LimF M Richards
Feb 1, 1994·Current Opinion in Genetics & Development·J Schlessinger
Sep 1, 1995·Current Biology : CB·A PandeyV M Dixit
Aug 1, 1995·Biochemical Society Transactions·C D Nobes, A Hall
Feb 15, 1996·Biochemical and Biophysical Research Communications·T KitamuraM Kasuga
May 1, 1996·The Biochemical Journal·G M BokochA E Traynor-Kaplan
May 24, 1996·The Journal of Biological Chemistry·G S FengJ Ni
Jul 19, 1996·The Journal of Biological Chemistry·J C ClemensJ E Dixon
Aug 30, 1996·The Journal of Biological Chemistry·M L GalisteoJ Schlessinger
Oct 18, 1996·The Journal of Biological Chemistry·G M BokochU G Knaus
Jul 1, 1996·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·R B BirgeH Hanafusa
Mar 15, 1997·The Biochemical Journal·Y KitamuraM Kasuga

❮ Previous
Next ❯

Citations

Aug 21, 2002·Trends in Cell Biology·Chad A Cowan, Mark Henkemeyer
May 16, 2013·Nature Communications·Alvaro Gutierrez-UzquizaMarcelo G Kazanietz
Nov 3, 2010·Genes & Development·Peter T HallockSteven J Burden
Jan 24, 2008·Molecular and Cellular Biology·Ivan M BlasutigTony Pawson
Jun 27, 2007·Molecular and Cellular Biology·Shengxi GuanWei Li
Oct 1, 2003·Molecular and Cellular Biology·Albéna PramatarovaBrian W Howell
Feb 25, 2003·Annual Review of Neuroscience·Genevieve Rougon, Oliver Hobert
Jul 22, 2011·Journal of Signal Transduction·Seisuke HattoriYutaka Harita
Jan 4, 2007·Proteome Science·Anouk EmadaliEric Chevet
Feb 4, 2009·Cell Communication and Signaling : CCS·Marcus LettauOttmar Janssen
Mar 25, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yi-Lan WengHeather T Broihier
May 16, 2009·Journal of the American Society of Nephrology : JASN·Nina JonesTony Pawson
Jun 14, 2005·International Journal of Biological Sciences·Yong Rao
Mar 29, 2014·Cell Communication and Signaling : CCS·Jatuporn NgoenkamSutatip Pongcharoen
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·James P FawcettTony Pawson
Apr 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shigeru HashimotoHisataka Sabe
Jun 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·G M RiveraB J Mayer
Jul 13, 2011·Journal of Signal Transduction·Juris A Grasis, Constantine D Tsoukas
Dec 29, 2011·Cellular and Molecular Life Sciences : CMLS·Eva NievergallPeter W Janes
Sep 2, 2011·Médecine sciences : M/S·Mélissa Labelle-Côté, Louise Larose
Nov 14, 2012·Molecular and Cellular Neurosciences·Nishi SrivastavaChristopher W Cowan
Nov 27, 2015·Molecular Biology of the Cell·Sofya BorinskayaBruce J Mayer
Jul 24, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Maninder KaurOm Silakari
Nov 16, 2014·Cell Communication and Signaling : CCS·Hui LiLouise Larose
Oct 7, 2008·Biochemical and Biophysical Research Communications·Eric Cardin, Louise Larose
May 18, 2004·Cell Motility and the Cytoskeleton·Hanna BrzeskaEdward D Korn
Nov 7, 2006·Biochimica Et Biophysica Acta·Stephanie HehlgansNils Cordes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.