NCR1+ cells appear early in GALT development of the ovine foetus and acquire a c-kit+ phenotype towards the end of gestation

Veterinary Immunology and Immunopathology
Line OlsenArild Espenes

Abstract

The amount, distribution and phenotype of ovine NCR1+ cells were investigated during developing GALT from day 70 of gestation. Antibodies against CD3 and CD79 were used to identify the compartments of GALT, and the localization of NCR1+ cells were correlated within these structures. Markers CD34 and c-kit, in addition to Ki67, were used to investigate possible origin and the stage of development of the NCR1+ cells. NCR1+ cells were present as single cells in the subepithelial tissue as early as 70 days of gestation, and were predominantly present in the T cell rich IFAs and domes as these intestinal wall compartments developed. While NCR1+ cells proliferated more intensively at mid-gestation (70-104 days), the number of NCR1+ cells also expressing c-kit, increased at the end of gestation. In conclusion, NCR1+ cells appeared early in T cell areas of the gut and displayed a phenotype consistent with intermediate stages of cNK cells and/or a subpopulation of ILC22.

References

Jan 1, 1991·Developmental and Comparative Immunology·M AleksandersenT Landsverk
Aug 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mark C ColesDimitris Kioussis
Nov 15, 2006·Immunological Reviews·Aharon G Freud, Michael A Caligiuri
Jan 29, 2008·Developmental and Comparative Immunology·Caroline Piercey AkessonMona Aleksandersen
Nov 13, 2009·Scandinavian Journal of Immunology·P Brandtzaeg
Oct 12, 2010·Science·Shinichiro SawaGérard Eberl
Feb 25, 2011·Veterinary Research·Timothy ConnelleyIvan W Morrison
Jan 10, 2012·Annual Review of Immunology·Hergen Spits, Tom Cupedo
May 9, 2012·Frontiers in Immunology·Kerim HoorwegTom Cupedo
May 15, 2012·Trends in Immunology·Claire PearsonFiona Powrie
Jan 26, 2013·Nature Reviews. Immunology·Hergen SpitsEric Vivier
Feb 11, 2014·Nature·Michael G ConstantinidesAlbert Bendelac
Feb 25, 2014·Seminars in Immunology·Elisa MontaldoMaria Cristina Mingari
Mar 26, 2014·Seminars in Immunology·Aharon G FreudMichael A Caligiuri
Apr 20, 2014·Frontiers in Immunology·Monica KilligChiara Romagnani

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