ncRNAs in Type-2 Immunity

Non-coding RNA
Riccardo GuidiMark S Wilson

Abstract

Immunological diseases, including asthma, autoimmunity and immunodeficiencies, affect a growing percentage of the population with significant unmet medical needs. As we slowly untangle and better appreciate these complex genetic and environment-influenced diseases, new therapeutically targetable pathways are emerging. Non-coding RNA species, which regulate epigenetic, transcriptional and translational responses are critical regulators of immune cell development, differentiation and effector function, and may represent one such new class of therapeutic targets. In this review we focus on type-2 immune responses, orchestrated by TH2 cell-derived cytokines, IL-4, IL-5 and IL-13, which stimulate a variety of immune and tissue responses- commonly referred to as type-2 immunity. Evolved to protect us from parasitic helminths, type-2 immune responses are observed in individuals with allergic diseases, including Asthma, atopic dermatitis and food allergy. A growing number of studies have identified the involvement of various RNA species, including microRNAs (miRNA) and long non-coding (lncRNA), in type-2 immune responses and in both clinical and pre-clinical disease settings. We highlight these recent findings, identify gaps in our und...Continue Reading

References

Feb 1, 1990·British Journal of Haematology·T MotojiH Mizoguchi
Jul 1, 1989·European Journal of Immunology·M LundgrenE Severinson
May 1, 1995·American Journal of Respiratory and Critical Care Medicine·A YokoyamaK Hiwada
Oct 1, 1993·Research in Immunology·J E de VriesG Aversa
Aug 30, 2001·Nature Immunology·M MohrsR M Locksley
Mar 5, 2003·Annual Review of Immunology·Thomas A Wynn
Oct 25, 2003·Clinical & Developmental Immunology·Vanessa UbaldiClaudio Pioli
Feb 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sung-Yun PaiI-Cheng Ho
Mar 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Javier Cote-SierraWilliam E Paul
May 12, 2004·Journal of Molecular Biology·Andrea Tanzer, Peter F Stadler
Jul 21, 2004·The Journal of Experimental Medicine·Amin Al-ShamiWarren J Leonard
Jul 31, 2004·Science·Jidong LiuGregory J Hannon
Aug 18, 2004·The Journal of Experimental Medicine·Booki MinWilliam E Paul
Aug 25, 2004·Biochemical and Biophysical Research Communications·Katsumi KasashimaTomoko Kozu
Oct 12, 2004·Nature Immunology·Jinfang ZhuWilliam E Paul
Oct 28, 2004·Proceedings of the National Academy of Sciences of the United States of America·Dong U Lee, Anjana Rao
May 4, 2005·The Journal of Experimental Medicine·Aleksandar DakicStephen L Nutt
Jun 9, 2005·The Journal of Biological Chemistry·Lars-Oliver TykocinskiAndreas Radbruch
Jun 25, 2005·The Journal of Biological Chemistry·Masakatsu YamashitaToshinori Nakayama
Jul 13, 2005·The Journal of Experimental Medicine·Stefan A MuljoKlaus Rajewsky
Sep 6, 2005·Nature Immunology·Baohua ZhouSteven F Ziegler
Sep 21, 2005·The Journal of Experimental Medicine·Amin Al-ShamiWarren J Leonard
Nov 18, 2005·Trends in Genetics : TIG·Ken C PangJohn S Mattick
Mar 23, 2006·Annual Review of Immunology·K Mark AnselAnjana Rao
Apr 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefan CostineanCarlo M Croce
Aug 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Konstantin D TaganovDavid Baltimore
Apr 28, 2007·Science·To-Ha ThaiKlaus Rajewsky
Apr 28, 2007·Science·Antony RodriguezAllan Bradley
Jun 15, 2007·The Journal of Experimental Medicine·Pornpimon AngkasekwinaiChen Dong
Sep 14, 2007·European Journal of Immunology·Mousa Komai-KomaFoo Y Liew
Sep 26, 2007·Nature Genetics·Michael KerteszEran Segal
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Esmerina TiliCarlo Maria Croce
Jan 15, 2008·Cell·Ana EulalioElisa Izaurralde
Feb 19, 2008·Nature·Jonathan B JohnnidisFernando D Camargo

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Datasets Mentioned

BETA
GM1278

Methods Mentioned

BETA
RNA-seq
biopsies
biopsy
bronchoalveolar lavage
HITS-CLIP

Software Mentioned

Morrbid
Morbid

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