NCX-701 (nitroparacetamol) is an effective antinociceptive agent in rat withdrawal reflexes and wind-up

British Journal of Pharmacology
E A Romero-SandovalJ F Herrero

Abstract

1. Non-steroidal anti-inflammatory drugs (NSAIDs) are effective anti-inflammatory and analgesic drugs although they also induce unwanted side effects due to the inhibition of the physiological effects regulated by prostaglandins. This has led to the search for new compounds with fewer side effects, such as the nitro-NSAIDs (NO-NSAIDs). Paracetamol is an analgesic drug devoid of some of the side effect of the NSAIDs but without anti-inflammatory activity. NCX-701 is a nitric oxide releasing version of paracetamol with anti-inflammatory and analgesic properties. 2. We have tested, in the single motor unit technique, the antinociceptive actions of intravenous cumulative doses of NCX-701 vs paracetamol, studying their antinociceptive effects in responses to noxious mechanical and electrical stimulation (wind-up). 3. Paracetamol did not induce any significant effect at the doses tested (maximum of 480 micromol kg(-1), 72.5 mg kg(-1)). NCX-701 however was very effective in reducing responses to noxious mechanical stimulation (32+/-10% of control response) and wind-up (ED(50) of 147+/-1 micromol kg(-1), 41.5+/-0.3 mg kg(-1)). The inhibition was not reversed by 1 mg kg(-1) of the opioid antagonist naloxone. In control experiments perfo...Continue Reading

References

Jan 1, 1989·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·B BannwarthA Gaucher
Aug 18, 1995·Neuroscience Letters·I NishiharaO Hayaishi
Jun 1, 1996·British Journal of Pharmacology·J F Herrero, P M Headley
May 16, 1997·Journal of Neuroscience Methods·R Solano, J F Herrero
Aug 4, 1999·Trends in Pharmacological Sciences·P del SoldatoA Pinto
Nov 5, 1999·Neuroscience Letters·J Mazario, J F Herrero
Feb 29, 2000·British Journal of Pharmacology·O A al-SwayehP K Moore
Mar 8, 2000·Progress in Neurobiology·J F HerreroJ A López-García
Jan 13, 2001·British Journal of Pharmacology·L E FutterP K Moore
Mar 16, 2001·Trends in Neurosciences·J P Kiss, E S Vizi
Apr 3, 2001·Brain Research·A M Sousa, W A Prado
Apr 27, 2001·Trends in Immunology·S Fiorucci
Jan 30, 2002·British Journal of Pharmacology·Gema Gaitán, Juan F Herrero

❮ Previous
Next ❯

Citations

Dec 4, 2003·European Journal of Pharmacology·Gema GaitánJuan F Herrero
Jan 20, 2004·European Journal of Pharmacology·Melanie Marshall, Philip K Moore
Jul 9, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·P K Moore, M Marshall
Jun 7, 2007·Journal of Neuroinflammation·M Mar Curros-Criado, Juan F Herrero
Jan 28, 2009·Current Rheumatology Reports·Matthias Hermann
Mar 11, 2005·Expert Opinion on Emerging Drugs·Lukas Radbruch, Frank Elsner
Apr 26, 2012·The Kaohsiung Journal of Medical Sciences·Kyong-Shil ImDong-Eon Moon
Sep 27, 2007·CNS Drug Reviews·E Alfonso Romero-SandovalJuan F Herrero
Aug 31, 2006·British Journal of Pharmacology·M MarshallP K Moore

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.