NDRG2 is expressed on enteric glia and altered in conditions of inflammation and oxygen glucose deprivation/reoxygenation.

Journal of Molecular Histology
Yuxin ZhangQiang Wang

Abstract

Enteric glial cells are more abundant than neurons in the enteric nervous system. Accumulating evidence has demonstrated that enteric glial cells share many properties with astrocytes and play pivotal roles in intestinal diseases. NDRG2 is specifically expressed in astrocytes and is involved in various diseases in the central nervous system. However, no studies have demonstrated the expression of NDRG2 in enteric glial cells. We performed immunostaining of adult mouse tissue, human colon sections, and primary enteric glial cells and the results showed that NDRG2 was widely expressed in enteric glial cells. Meanwhile, our results showed that NDRG2 was upregulated after treatment with pro-inflammatory cytokines and exposure to oxygen glucose deprivation/reoxygenation, indicating that NDRG2 might be involved in these conditions. Moreover, we determined that NDRG2 translocated to the nucleus after treatment with pro-inflammatory cytokines but not after exposure to oxygen glucose deprivation/reoxygenation. This study is the first to show the expression and distribution of NDRG2 in the enteric glia. Our results indicate that NDRG2 might be involved in the pathogenesis of enteric inflammation and ischemia/reperfusion injury. This stud...Continue Reading

References

Mar 1, 1971·Zeitschrift Für Naturforschung. Teil B. Anorganische Chemie, Organische Chemie, Biochemie, Biophysik, Biologie·G Gabella
Nov 1, 2001·Proceedings of the National Academy of Sciences of the United States of America·A CornetR S Liblau
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Yanchun DengMarie Chia-mi Lin
Mar 3, 2004·Annals of the New York Academy of Sciences·Nancy R Nichols
Jun 23, 2004·Neurobiology of Disease·Cathy MitchelmoreNiels A Jensen
Jun 30, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C CirilloR Cuomo
Sep 16, 2009·European Journal of Pharmacology·Carlos Rodrigo Cámara-LemarroyNancy Esthela Fernández-Garza
Aug 26, 2011·The Journal of Clinical Investigation·Michael D Gershon
Aug 11, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Roberto De GiorgioMichel Neunlist
Aug 15, 2012·Nature Reviews. Gastroenterology & Hepatology·Brian D Gulbransen, Keith A Sharkey
Nov 6, 2012·European Journal of Pharmacology·Marcela Julio-PieperJohn F Cryan
Dec 18, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yan LiLibo Yao
Feb 27, 2014·Nature Communications·Shingo NakahataKazuhiro Morishita
May 13, 2014·Cell and Tissue Research·Gabriele FlüggeEberhard Fuchs
Feb 3, 2015·European Journal of Pharmacology·Viviana FilpaFrancesca Crema
Jul 26, 2015·Cellular Signalling·Tomonaga IchikawaKazuhiro Morishita
Sep 6, 2015·Acta Biochimica Et Biophysica Sinica·Kaifeng LinYan Li
Jan 16, 2016·Cellular and Molecular Gastroenterology and Hepatology·Isola A M BrownBrian D Gulbransen
Jan 14, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Simone LangnessTodd W Costantini
Feb 18, 2017·Cancer Research·Tomohiro TamuraKazuhiro Morishita
Mar 2, 2017·World Journal of Clinical Oncology·Anders Lorentzen, Cathy Mitchelmore
Oct 24, 2017·The Journal of Clinical Investigation·Yan LiLize Xiong
Mar 9, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Camille PochardMalvyne Rolli-Derkinderen
Jul 24, 2018·Biochimica Et Biophysica Acta. General Subjects·Nathalie VaesVeerle Melotte
Sep 4, 2018·Journal of Visualized Experiments : JoVE·Zhen WangJuanita L Merchant
Mar 11, 2020·Nature Reviews. Gastroenterology & Hepatology·Nick J Spencer, Hongzhen Hu

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