NDRG4, a novel candidate tumor suppressor, is a predictor of overall survival of colorectal cancer patients

Oncotarget
Dake ChuJianyong Zheng

Abstract

The role of NDRG4 in human malignancies is largely unknown. We investigated the role of NDRG4 protein in colorectal cancer and its prognostic value in a hospital-based retrospective training cohort of 272 patients and a prospective validation cohort of 708 patients were. Cell line was transfected with an NDRG4 expression construct to confirm the suppression of PI3K-AKT activity by NDRG4. Appropriate statistical methods were utilized for analysis. Results showed that NDRG4 protein expression was significantly decreased from normal mucosa, chronic colitis, ulcerative colitis, atypical hyperplasia to colorectal cancer. Significant negative correlations were found between NDRG4 staining and p-AKT. Patients with positive NDRG4 staining had favorable survival in both study cohorts. In multivariate analysis, NDRG4 staining proved to be an independent predictor of overall survival. Moreover, the prognostic role of NDRG4 was stratified by p-AKT. Overexpression of NDRG4 in colorectal cancer cell can significantly suppress PI3K-AKT activity, even after EGF stimulation. These results indicated NDRG4 protein expression was decreased in colorectal cancer. It may play its tumor suppressive role in carcinogenesis and progression through attenu...Continue Reading

References

Jul 14, 1998·Nature Medicine·J KononenO P Kallioniemi
Apr 30, 2002·Brain Research. Developmental Brain Research·Takeshi OhkiMinoru Takeda
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Yanchun DengMarie Chia-mi Lin
Aug 29, 2003·Biochemical and Biophysical Research Communications·Jun-ichi KyunoMakoto Asashima
Mar 3, 2004·Annals of the New York Academy of Sciences·Nancy R Nichols
Nov 5, 2004·World Journal of Gastroenterology : WJG·Xiao-Lan HuLi-Bo Yao
Jul 29, 2005·The Journal of Molecular Diagnostics : JMD·Shuji OginoCharles S Fuchs
Oct 4, 2006·Molecular and Cellular Biology·Amit KumarAna C Carrera
Oct 27, 2006·The Journal of Molecular Diagnostics : JMD·Shuji OginoCharles S Fuchs
Feb 24, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vijayalakshmi ThamilselvanMarc D Basson
Nov 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Polly A NewcombUNKNOWN Colon Cancer Family Registry
Nov 14, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Tomohiko OkudaToshiyuki Miyata
Jun 3, 2008·Neoplasia : an International Journal for Oncology Research·Katsuhiko NoshoShuji Ogino
Jul 8, 2008·Acta Biochimica Et Biophysica Sinica·Libo YaoXuewu Liu
Aug 19, 2008·International Journal of Cancer. Journal International Du Cancer·Martin TepelMarkus J Riemenschneider
Jun 19, 2009·Journal of the National Cancer Institute·Veerle MelotteManon van Engeland
Jul 11, 2009·Current Opinion in Pharmacology·Sarah Kraus, Nadir Arber
Jul 14, 2009·The Journal of Biological Chemistry·Stephen H SchillingMichael B Datto
Jul 25, 2009·Nature Reviews. Cancer·Jeffrey A Engelman
Sep 17, 2009·Current Colorectal Cancer Reports·Beth B McConnell, Vincent W Yang
Dec 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Akihiko YoshizawaWilliam D Travis
Jul 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Veerle MelotteManon van Engeland
Jan 12, 2011·Molecular Cancer Therapeutics·Dake ChuJian Zhang
Jun 4, 2011·The Journal of Biological Chemistry·Hitomi YamamotoToshiyuki Miyata
Jul 5, 2011·Gastroenterology·Jing ZhangRamesh A Shivdasani
Apr 12, 2012·Omics : a Journal of Integrative Biology·Wenchao DingBiaoyang Lin
May 9, 2012·Experimental and Molecular Pathology·Manpreet Kaur Saini, Sankar Nath Sanyal
Aug 18, 2012·Cancer Cell·Sandrine SanderKlaus Rajewsky
Nov 20, 2012·Seminars in Immunopathology·Sergei I Grivennikov
Nov 20, 2012·International Journal of Cancer. Journal International Du Cancer·Adetunji T ToriolaCornelia M Ulrich
Apr 4, 2013·Gut Microbes·Janelle C Arthur, Christian Jobin
Apr 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Erin M CoffeeKenneth E Hung
Sep 21, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Hansong WangLoïc Le Marchand
Jan 8, 2014·Oncotarget·Maria Giovanna Francipane, Eric Lagasse

❮ Previous
Next ❯

Citations

Aug 7, 2019·Therapeutic Advances in Gastroenterology·Chaoran YuMinhua Zheng
Mar 4, 2018·Molecular Carcinogenesis·Zixi ZhangDake Chu
May 20, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N VaesV Melotte
Mar 2, 2021·World Journal of Gastrointestinal Surgery·Yao Liu, Fang-Xing Peng
Oct 2, 2021·Oncology Letters·Ruikai LiJianyong Zheng

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
PMA
surgical resection
PCR

Software Mentioned

SPSS

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.