NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition

Brain Research
Tianda ChenDai Zhang

Abstract

Abnormalities during brain development are tightly linked several psychiatric disorders. Mutations in NADH dehydrogenase ubiquinone flavoprotein 2 (NDUFV2) are responsible for schizophrenia, bipolar disorder and Parkinson׳s disease. However, the function of NDUFV2 during brain development remains unclear. Here we reported that ndufv2 is expressed in the developing cerebral cortex. In utero suppression of ndufv2 arrested neuronal migration, leading to accumulation of ectopic neurons in the intermediate zone. ndufv2 inhibition did not affect radial glia scaffold, progenitor cells or neurons survival. However, the loss of ndufv2 impairs neuronal multipolar-bipolar transition in vivo and polarization in vitro. Moreover, ndufv2 affected actin cytoskeleton and tubulin stabilization in cortical neurons. Overall, our findings establish a new NDUFV2 dependent mechanism underlying neuronal migration and psychiatric disorders.

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Citations

Apr 28, 2017·Hippocampus·Meghraj Singh Baghel, Mahendra Kumar Thakur
May 19, 2017·Cellular and Molecular Life Sciences : CMLS·Toshifumi Fukuda, Shigeru Yanagi
Jun 1, 2018·Clinical and Experimental Pharmacology & Physiology·Eyal Asor, Dorit Ben-Shachar
Dec 12, 2018·Molecular Psychiatry·Oded BergmanDorit Ben-Shachar

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