DOI: 10.1101/471771Nov 19, 2018Paper

NDV-3A vaccination protects mice from Candida albicans biofilm infection

BioRxiv : the Preprint Server for Biology
Abdullah AlqarihiPriya Uppuluri

Abstract

NDV-3A, a novel fungal vaccine undergoing clinical trials, contains a recombinant version of the Candida albicans rAls3 N-terminus protein (rAls3p-N) in aluminum hydroxide. In a Phase 1b/2a clinical trial, NDV-3A protected women from recurrent vulvovaginal candidiasis. Here, we reveal that active immunization in mice with NDV-3A induces high titers of anti-rAls3p-N antibodies that interfere with C. albicans ability to adhere to and invade endothelial cells, and form biofilm in vitro. The anti-rAls3p-N antibodies also protect against C. albicans biofilm formation in a central venous catheter mouse model. Finally, anti-rAls3p-N antibodies significantly inhibit yeast dispersal from the hyphal layers of biofilms. Overall these preclinical studies suggest that NDV-3A may serve as an immunotherapeutic strategy for prevention of infections on indwelling medical devices.

Related Concepts

Aluminum Hydroxide
Candida albicans
Clinical Trials
Fungal Vaccines
Immunotherapy
Medical Devices
Laboratory mice
Vaccination
Woman
Yeasts

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