Neanderthal-Denisovan ancestors interbred with a distantly related hominin

Science Advances
Alan R RogersAlan A Achenbach

Abstract

Previous research has shown that modern Eurasians interbred with their Neanderthal and Denisovan predecessors. We show here that hundreds of thousands of years earlier, the ancestors of Neanderthals and Denisovans interbred with their own Eurasian predecessors-members of a "superarchaic" population that separated from other humans about 2 million years ago. The superarchaic population was large, with an effective size between 20 and 50 thousand individuals. We confirm previous findings that (i) Denisovans also interbred with superarchaics, (ii) Neanderthals and Denisovans separated early in the middle Pleistocene, (iii) their ancestors endured a bottleneck of population size, and (iv) the Neanderthal population was large at first but then declined in size. We provide qualified support for the view that (v) Neanderthals interbred with the ancestors of modern humans.

References

Sep 1, 1993·Journal of Molecular Evolution·M Nei, N Takahata
Sep 2, 2005·Nature·UNKNOWN Chimpanzee Sequencing and Analysis Consortium
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·J J Hublin
Jun 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Reid FerringDavid Lordkipanidze
Mar 9, 2012·Nature·Aylwyn ScallyRichard Durbin
Sep 1, 2012·Science·Matthias MeyerSvante Pääbo
Dec 20, 2013·Nature·Kay PrüferSvante Pääbo
Feb 5, 2014·Nature Reviews. Genetics·Krishna R Veeramah, Michael F Hammer
Jan 27, 2016·Proceedings of the National Academy of Sciences of the United States of America·Guy Amster, Guy Sella
Feb 18, 2016·Nature·Martin KuhlwilmSergi Castellano
Apr 2, 2016·Science·David GordonEvan E Eichler
Aug 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Alan R RogersChad D Huff
Oct 7, 2017·Science·Kay PrüferSvante Pääbo
Nov 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Alan R RogersChad D Huff
Nov 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Fabrizio Mafessoni, Kay Prüfer
Apr 15, 2019·Cell·Guy S JacobsMurray P Cox

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Citations

Feb 12, 2021·Nature·Anders BergströmPontus Skoglund
Apr 27, 2021·IScience·Miguel Caparros, Sandrine Prat
May 28, 2021·Pathologica·Raffaele Gaeta
Jul 29, 2021·PloS One·Silvana CondemiJacques Chiaroni
Aug 31, 2021·Annals of Human Biology·Javier G SerranoRosa Fregel
May 25, 2021·Genome Biology and Evolution·K D AhlquistKelsey E Witt
Oct 31, 2021·Nature Communications·Kai YuanShuhua Xu

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