PMID: 6603258Aug 1, 1983

Near-haploid cell line in the blastic crisis of chronic myelogenous leukemia: a possible marker for lymphoid malignancy

Cancer Genetics and Cytogenetics
T M NajafzadehJ Katz

Abstract

The blast cells of a 14-year-old patient in the blastic phase of chronic myelogenous leukemia (CML) were studied. Cellular morphology, presence of the enzyme terminal deoxynucleotidyl transferase (TdT), and reactivity to the common acute lymphoblastic leukemia antiserum (CALLA) substantiated a lymphoid blast cell line. Immunologic surface markers were nonreactive for E-rosette (T) cells and immunoglobulin-bearing (B) cells. Cytogenetic, studies revealed persistance of the Philadelphia chromosome and a near-haploid cell line, i.e., 28,XY,t(9;22), +14, +15, +21, +22(GTG). The patient responded to chemotherapy with vincristine, prednisone, and L-asparaginase, first line drugs used for remission-induction of acute lymphoblastic leukemia in childhood. We suggest that severe hypodiploidy or near-haploidy, along with TdT and CALLA, may provide more accurate prognostic information in patients with CML and the lymphoid blastic crisis.

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Citations

Mar 15, 1985·Cancer Genetics and Cytogenetics·S MisawaJ R Testa
Apr 1, 1985·Cancer Genetics and Cytogenetics·E Yao
Jan 15, 1986·Cancer Genetics and Cytogenetics·U KristofferssonF Mitelman
Apr 1, 1991·Cancer Genetics and Cytogenetics·C SreekantaiahA A Sandberg
Aug 26, 2003·Cancer Genetics and Cytogenetics·P K DasA Smith
Feb 25, 2005·Genome Génome / Conseil National De Recherches Canada·Karine BouillySylvie Lapègue
Jun 21, 2014·FEBS Letters·Ulrich Elling, Josef M Penninger
Aug 1, 1993·Genes, Chromosomes & Cancer·V DrouinB Debesse
Jan 1, 1988·Pediatric Hematology and Oncology·I NordensonE Forestier
Oct 3, 2020·Computational and Structural Biotechnology Journal·Shengyi SunLing Shuai

Related Concepts

Teens
B-Lymphocytes
Autosome Abnormalities
Chromosomes, Human,21-22
Haploid Cell
Karyotype Determination Procedure
Leukemia, Monocytic, Chronic
Lymphoid Cells
Immunocytoadherence
T-Lymphocyte

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