Near haploidy in breast cancer: a particular pathway of chromosome evolution

Cancer Genetics and Cytogenetics
D FlagielloB Dutrillaux

Abstract

In a series of 260 cytologically abnormal breast cancers studied in our laboratory, we observed a single case of near-haploid karyotype: 27,X, +der(1;16)(q10;p10), +7, +14, +15. A review of published cases of near-haploid malignancies suggests that near haploidy belongs to a process of chromosome evolution distinct from that of most epithelial cancers in which hypodiploidy is strongly associated with the occurrence of unbalanced structural rearrangements. In near-haploid tumors, chromosome loss is independent from chromosome rearrangements and may not be associated with an adverse prognosis.

References

Jun 1, 1992·Cancer Genetics and Cytogenetics·C OrndalF Mitelman
Jun 1, 1992·Genes, Chromosomes & Cancer·N OnoderaC M Rubin
Jan 1, 1992·Breast Cancer Research and Treatment·H MagdelenatB Dutrillaux
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Jan 1, 1990·Cancer Genetics and Cytogenetics·M MulerisB Dutrillaux
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Citations

Feb 19, 2002·Cancer Genetics and Cytogenetics·Reza MirfakhraieParvin Mehdipour
Mar 24, 2010·Seminars in Diagnostic Pathology·Emad A Rakha, Ian O Ellis
Jun 8, 2001·American Journal of Clinical Pathology·S StaibanoUNKNOWN Association of Directors of Anatomic and Surgical Pathology
Mar 8, 2005·Genes, Chromosomes & Cancer·Romain MolistMartine Muleris
Nov 21, 1998·Genes, Chromosomes & Cancer·D FlagielloB Dutrillaux
Mar 20, 2014·Development·Anton Wutz

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