PMID: 3152977Jan 1, 1988

Near-haploidy in childhood leukemia: a high-risk component

Pediatric Hematology and Oncology
I NordensonE Forestier

Abstract

We present a 4-year-old girl with acute lymphocytic leukemia (ALL) and only 25 chromosomes at cytogenetic examination of her bone marrow. Severe hypodiploidy is extremely rare in childhood leukemia and is almost exclusively associated with ALL. To our knowledge only six cases with banded metaphases have been published. The chromosome number in the present case is the lowest ever reported. Our patient as well as other reported cases have disomy for chromosome 21. The prognosis for ALL with hypodiploidy is poor with a reported mean survival of 9 months. All published patients are females.

References

Dec 1, 1979·American Journal of Clinical Pathology·F ShabtaiM Djaldetti
Jan 1, 1979·American Journal of Hematology·R ComoR S Sparkes
Mar 1, 1987·British Journal of Haematology·R P Gale, I Ben Bassat
Mar 15, 1985·Cancer Genetics and Cytogenetics·S MisawaJ R Testa
Aug 1, 1982·British Journal of Haematology·G TricotR L Verwilghen
Jul 1, 1984·British Journal of Haematology·S A StassG V Dahl
Jan 1, 1982·Medical and Pediatric Oncology·G A HoeltgeM L Slovak

Related Concepts

Marrow
Haploid Cell
Karyotype Determination Procedure
Leukemia, Lymphocytic, Acute, L2

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