Near-infrared fluorescent probe for imaging mitochondrial hydrogen polysulfides in living cells and in vivo

Analytical Chemistry
Min GaoLingxin Chen

Abstract

Hydrogen polysulfides (H2Sn, n > 1), derived from hydrogen sulfide (H2S), have attracted increasing attention in biochemical research, which may perform as the actual signaling molecules during cell signaling processes. Because of the closed biological and chemical relationship between H2S and H2Sn, it is of great value to develop sensitive and specific techniques to distinguish the intracellular level of H2Sn. To improve the understanding of the physiological and pathological roles played by H2Sn, we now develop a specific fluorescent probe Mito-ss for capturing H2Sn in cells and in vivo. When triggered by H2Sn, Mito-ss replies a turn-on fluorescence signal and exhibits a higher selectivity toward H2Sn than other abundant competing biothiols, such as glutathione, cysteine and H2S. The probe Mito-ss can also be applied to visual H2Sn in living cells, as well as in vivo, providing a potentially powerful approach for probing H2Sn in biological systems.

References

Dec 15, 1989·The Biochemical Journal·J I Toohey
Nov 14, 2001·Free Radical Biology & Medicine·G I GilesC Jacob
Jun 29, 2004·Amino Acids·P Kamoun
Aug 19, 2007·Nature·Toren FinkelMaria A Blasco
Apr 19, 2008·Nature Chemical Biology·Christine C Winterbourn
May 16, 2008·Antioxidants & Redox Signaling·Alberto BindoliHenry Jay Forman
Jun 10, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Albert Tangerman
May 27, 2010·Chemical Society Reviews·Xiaoqiang ChenJuyoung Yoon
Sep 18, 2010·Chemical Research in Toxicology·Péter Nagy, Christine C Winterbourn
Sep 8, 2011·Angewandte Chemie·Chunrong LiuMing Xian
Oct 18, 2011·Archives of Biochemistry and Biophysics·Nestor E FrancoleonJon M Fukuto
Mar 22, 2012·Antioxidants & Redox Signaling·Benjamin Lee PredmoreGabriel Gojon
Jun 19, 2012·Chemical Reviews·Yuming YangFuyou Li
Jul 12, 2012·Nature Reviews. Molecular Cell Biology·Bindu D Paul, Solomon H Snyder
Aug 28, 2012·Current Opinion in Chemical Biology·Vivian S Lin, Christopher J Chang
Nov 9, 2012·Analytical Chemistry·Takeaki OzawaSung Bae Kim
Nov 24, 2012·Nature Chemistry·Jefferson ChanChristopher J Chang
Feb 16, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuka KimuraHideo Kimura
Mar 22, 2013·Chemical Reviews·Candice E Paulsen, Kate S Carroll
Apr 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Vivian S LinChristopher J Chang
May 8, 2013·Antioxidants & Redox Signaling·Romy GreinerTobias P Dick
Jun 19, 2013·Biochimica Et Biophysica Acta·Péter NagyAnita Vasas
Jul 9, 2013·Chemical Communications : Chem Comm·Sankarprasad BhuniyaJong Seung Kim
Sep 17, 2013·Neurochemistry International·Hideo Kimura
Jan 15, 2014·Biochimica Et Biophysica Acta·Omer KabilRuma Banerjee
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tomoaki IdaTakaaki Akaike
May 9, 2014·Journal of the American Chemical Society·Chunrong LiuMing Xian
Jul 11, 2014·Journal of the American Chemical Society·T Spencer BaileyMichael D Pluth

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Citations

Aug 20, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hengli YangYunyou Duan
Mar 29, 2018·Chemical Communications : Chem Comm·Anila Hoskere AAmitava Das
May 18, 2016·Chemical Society Reviews·Yuan Ge, Donal F O'Shea
Aug 9, 2017·Organic & Biomolecular Chemistry·Neha GuptaManoj Kumar
Mar 21, 2017·Chemical Society Reviews·Min GaoLingxin Chen
Aug 8, 2018·Dalton Transactions : an International Journal of Inorganic Chemistry·Ananya DuttaMahammad Ali
Oct 12, 2018·Chemical Communications : Chem Comm·Hong Huang, Yang Tian
Nov 30, 2018·Chembiochem : a European Journal of Chemical Biology·Hardev SinghJong Seung Kim
Apr 19, 2018·British Journal of Pharmacology·Heng LiuMing Xian
Apr 16, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yasuhiro Shinkai, Yoshito Kumagai
Jan 23, 2016·Journal of Clinical Biochemistry and Nutrition·Yoko TakanoKenjiro Hanaoka
Jan 15, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yue WangLingxin Chen
Nov 24, 2017·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Jagadish Katla, Sriram Kanvah
Aug 31, 2019·Analytical and Bioanalytical Chemistry·Xiangpeng LinFangong Kong
Feb 6, 2020·Essays in Biochemistry·Dayana BenchoamBeatriz Alvarez
Sep 11, 2018·Small Methods·Ling Huang, Gang Han
Nov 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kun DouJinmao You
Apr 14, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jianhua MaXiaojun Peng
Nov 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Min GaoLingxin Chen
Jul 21, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Dapeng ChenXiaochen Dong
Oct 22, 2015·Methods and Applications in Fluorescence·Christoph Staudinger, Sergey M Borisov

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