Near-Infrared Heptamethine Cyanine Based Iron Oxide Nanoparticles for Tumor Targeted Multimodal Imaging and Photothermal Therapy

Scientific Reports
Sejy LeeYong Yeon Jeong

Abstract

Near-infrared fluorescent (NIRF) imaging modality holds great promise for tumor detection and offers several advantages of bioimaging, such as high tissue penetration with less background scattering. The disadvantage of NIRF bioimaging is that it has very low spatial resolution. Thus, the combination of NIRF with magnetic resonance imaging (MRI) is a good option because MRI can provide anatomical information with a higher resolution. Heptamethine cyanine dye (MHI-148) has been reported to have tumor-targeting capability which was used here as the NIRF agent. DSPE-SPION nanoparticles were synthesized by the solvent hydration method and conjugated with MHI-148 dye to form a MRI/NIRF dual imaging probe. The size and charge of the MHI-DSPE-SPION were found to be about 84 ± 6 nm and 3.7 mV by DLS & Zeta Potential analysis. In vivo MRI of the SCC7 tumor showed an enhanced accumulation of MHI-DSPE-SPION, peaking at day 1, compared to 4 hrs with the control DSPE-SPION. An in vivo photothermal tumor reduction study was done on the SCC7 tumor of BALB/c nude mice. Tumor reduction study showed complete tumor removal after 8 days. In conclusion, MHI-DSPE-SPION can be used as a cancer theranostics material because it provides MRI-optical ima...Continue Reading

References

Nov 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyuk Sang Yoo, Tae Gwan Park
Jul 24, 2008·Lasers in Surgery and Medicine·Jihoon KimThomas E Milner
Apr 21, 2010·AAPS PharmSciTech·Juma Masoud Abdulla AbdullaYusrida Darwis
Apr 23, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiaojian YangLeland W K Chung
Jul 5, 2011·Biomaterials·Shenglin LuoChunmeng Shi
Oct 14, 2011·Physical Chemistry Chemical Physics : PCCP·Johannes MöllerMetin Tolan
Dec 25, 2012·Biomaterials·Shenglin LuoChunmeng Shi
Jan 26, 2013·Journal of Photochemistry and Photobiology. B, Biology·Supriya SrinivasanAnthony J McGoron
Feb 23, 2013·Journal of Drug Delivery·Veronika Buxhofer-AuschTheresia Thalhammer
Aug 6, 2013·International Journal of Molecular Sciences·Reju ThomasYong Yeon Jeong
Sep 26, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lin ZhuVladimir P Torchilin
Nov 26, 2013·Advanced Drug Delivery Reviews·Nicolas BertrandOmid C Farokhzad
Oct 23, 2014·International Journal of Nanomedicine·Alicia Fernandez-FernandezAnthony J McGoron
Feb 6, 2015·Chemical Society Reviews·Tae-Hyun ShinJinwoo Cheon
Sep 9, 2015·Nature Biotechnology·Elvin BlancoMauro Ferrari
Dec 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Huihui WangMingqian Tan

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Citations

May 31, 2018·Nanoscale·Ashish TiwariJaspreet K Randhawa
Feb 17, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Reju George ThomasYong Yeon Jeong
Oct 17, 2018·Nanoscale·Arathyram Ramachandra Kurup SasikalaCheol Sang Kim
Jan 30, 2020·Advanced Healthcare Materials·Miguel M LeitãoIlídio J Correia
Aug 12, 2020·Journal of Fluorescence·Xiaotian XiaXiaoli Lan
Jun 2, 2018·Journal of Immunology Research·Wei LvLi Zhang
Apr 11, 2020·Beilstein Journal of Organic Chemistry·Bernd StrehmelHeinz Mustroph
Jan 31, 2020·Nano Letters·Joshua C KaysAllison M Dennis
Sep 23, 2021·Journal of the American Chemical Society·Arezoo ShahrivarkevishahiJeremiah J Gassensmith

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Methods Mentioned

BETA
imaging technique
fluorescence imaging
transmission electron microscopy

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