Near-infrared laser adjuvant for influenza vaccine

PloS One
Satoshi KashiwagiMark C Poznansky

Abstract

Safe and effective immunologic adjuvants are often essential for vaccines. However, the choice of adjuvant for licensed vaccines is limited, especially for those that are administered intradermally. We show that non-tissue damaging, near-infrared (NIR) laser light given in short exposures to small areas of skin, without the use of additional chemical or biological agents, significantly increases immune responses to intradermal influenza vaccination without augmenting IgE. The NIR laser-adjuvanted vaccine confers increased protection in a murine influenza lethal challenge model as compared to unadjuvanted vaccine. We show that NIR laser treatment induces the expression of specific chemokines in the skin resulting in recruitment and activation of dendritic cells and is safe to use in both mice and humans. The NIR laser adjuvant technology provides a novel, safe, low-cost, simple-to-use, potentially broadly applicable and clinically feasible approach to enhancing vaccine efficacy as an alternative to chemical and biological adjuvants.

References

Jun 1, 1988·Archives of Dermatology·T B Fitzpatrick
Sep 1, 1968·American Industrial Hygiene Association Journal·D H Sliney, W A Palmisano
Jan 1, 1995·Pharmaceutical Biotechnology·R K GuptaG R Siber
Apr 1, 1995·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·R AshinoffN A Soter
Jan 23, 1999·Journal of Immunological Methods·A FreyD Zurakowski
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F RahmanH F Löhr
Aug 29, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Ronald W EnglandLarry Hagan
Aug 20, 2003·The Journal of Experimental Medicine·Alfonso MartIn-FontechaFederica Sallusto
Nov 16, 2004·Nature Immunology·Randall L LindquistMichel C Nussenzweig
Apr 7, 2005·Nature Medicine·Jan Holmgren, Cecil Czerkinsky
Feb 24, 2006·Nature Reviews. Immunology·Marian R Neutra, Pamela A Kozlowski
Feb 24, 2006·Emerging Infectious Diseases·Paul G ThomasPeter C Doherty
Sep 9, 2006·Clinical and Vaccine Immunology : CVI·Victor C HuberJonathan A McCullers
Oct 10, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert L AtmarRobert B Couch
Feb 16, 2007·The New England Journal of Medicine·Robert B BelsheUNKNOWN CAIV-T Comparative Efficacy Study Group
Jun 26, 2007·Nature Reviews. Immunology·José A Villadangos, Petra Schnorrer
Jun 29, 2007·Clinical and Vaccine Immunology : CVI·Solveig HaugeLars Reinhardt Haaheim
Oct 5, 2007·The New England Journal of Medicine·Kristin L NicholEelko Hak
Feb 12, 2008·The Journal of Infectious Diseases·David I BernsteinHeather Hill
May 20, 2008·Vaccine·Paul Henri Lambert, Philippe E Laurent
Sep 5, 2008·Current Protocols in Microbiology·Kristy J SzretterJacqueline M Katz
Sep 19, 2008·Immunity·David AlvarezUlrich H von Andrian
Nov 26, 2008·Handbook of Experimental Pharmacology·Alfonso Martín-FontechaFederica Sallusto
Dec 2, 2008·PLoS Pathogens·Lai Guan NgWolfgang Weninger
Mar 3, 2009·Expert Review of Vaccines·Ali M HarandiOle F Olesen
Mar 11, 2009·PloS One·Dimitrios G KoutsonanosIoanna Skountzou
Apr 8, 2009·Expert Review of Vaccines·Frederick R VogelJean Haensler
May 5, 2009·Current Protocols in Microbiology·Yumiko MatsuokaKanta Subbarao
Sep 19, 2009·Nature Reviews. Immunology·Frank O NestleBrian J Nickoloff
Sep 22, 2009·Current Topics in Microbiology and Immunology·Mark R PrausnitzAlexander K Andrianov
Oct 27, 2009·Nature Reviews. Immunology·Jerrold R Turner
Nov 20, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Igor M Belyakov, Jeffrey D Ahlers
Jul 20, 2010·Nature Medicine·Sean P SullivanMark R Prausnitz
Oct 30, 2010·Immunity·Robert L CoffmanRobert A Seder

❮ Previous
Next ❯

Citations

Apr 12, 2014·Photomedicine and Laser Surgery·Raymond J Lanzafame
Feb 16, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Akikazu Sakudo
Jan 18, 2016·Journal of Photochemistry and Photobiology. B, Biology·Chih-Hung LeeHsin-Su Yu
Feb 14, 2015·Biotechnology and Bioengineering·Piergiuseppe NestolaManuel J T Carrondo
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Satoshi KashiwagiMark C Poznansky
May 20, 2014·Human Vaccines & Immunotherapeutics·Eva M Riedmann
Apr 4, 2017·Vaccine·Yoshifumi KimizukaSatoshi Kashiwagi
Jul 16, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kaitlyn MorseSatoshi Kashiwagi
Nov 14, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yoshifumi KimizukaSatoshi Kashiwagi
Sep 8, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jeffrey A GelfandMark C Poznansky
Jan 30, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Satoshi Kashiwagi
Nov 3, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Patrick M ReevesMark C Poznansky
Jul 2, 2020·Photobiomodulation, Photomedicine, and Laser Surgery·Praveen R Arany
Nov 12, 2016·Advanced Functional Materials·Ki Su KimSeok Hyun Yun
Mar 9, 2015··Richard Levenson, Richard Levenson

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
flow cytometry
confocal microscopy
PCR
FACS

Software Mentioned

Image J

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.