Near-infrared laser mediated modulation of ice crystallization by two-dimensional nanosheets enables high-survival recovery of biological cells from cryogenic temperatures

Nanoscale
Fazil PanhwarGang Zhao

Abstract

Two-dimensional (2D) graphene oxide (GO) and molybdenum disulfide (MoS2) nanosheets (NSs) have been widely used as photothermal agents and as potential carriers of antitumor drugs. Their spatial thermal effects have been extensively explored for use at physiological and hyperthermic temperatures (37 to 46 °C). Furthermore, the modulation of the spatial thermal distributions with these NSs may have even more profound applications in the microstructural control of biomaterials at cryogenic temperatures (-196 to 37 °C). These applications include bioinspired microfabrication via freezing, food and drug freeze-drying, and biomaterial cryopreservation. However, such thermal effects of NSs and their applications at cryogenic temperatures had never been fully explored. Therefore, in this study, we have utilized the near-infrared laser induced photothermal effects of GO and MoS2 NSs to suppress the ice nucleation and ice crystal growth during warming of the biosamples. Using this approach, biological cells subjected to fast cooling to a deeply frozen state (-196 °C) were successfully recovered with high survival rates and full biological functionality. Thus, we provide a NS based effective approach to control the crystallization behavi...Continue Reading

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Citations

Jan 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lingxiao ShenGang Zhao
Jun 9, 2020·Colloids and Surfaces. B, Biointerfaces·Jiaying LuJingjing Li
Feb 9, 2021·Cryobiology·Emily N GallichotteJennifer P Barfield
Mar 23, 2021·Advanced Science·Tie Chang, Gang Zhao
May 25, 2021·ACS Biomaterials Science & Engineering·Faryal Farooq CheepaKashan Memon
Aug 18, 2021·Cryobiology·Akalabya Bissoyi, Ido Braslavsky
Jul 10, 2021·Trends in Biotechnology·Mengjia DouWei Rao

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Methods Mentioned

BETA
surface plasmon resonance
AFM
dynamic light scattering
X-ray
biosensor
irradiated
light scattering
Fluorescence

Software Mentioned

Image J

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