Near-infrared light (670 nm) reduces MPTP-induced parkinsonism within a broad therapeutic time window

Experimental Brain Research
F ReinhartC Moro

Abstract

We have shown previously that near-infrared light (NIr), when applied at the same time as a parkinsonian insult (e.g. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP), reduces behavioural deficits and offers neuroprotection. Here, we explored whether the timing of NIr intervention-either before, at the same time or after the MPTP insult-was important. Mice received MPTP injections (total of 50 mg/kg) and, at various stages in relation to these injections, extracranial application of NIr. Locomotor activity was tested with an open-field test, and brains were processed for immunohistochemistry. Our results showed that regardless of when NIr was applied in relation to MPTP insult, behavioural impairment was reduced by a similar magnitude. The beneficial effect of NIr was fast-acting (within minutes) and long-lasting (for several days). There were more dopaminergic cells in the NIr-treated MPTP groups than in the MPTP group; there was no clear indication that a particular combination of NIr treatment and MPTP injection resulted in a higher cell number. In summary, irrespective of whether it was applied before, at the same time as or after MPTP insult, NIr reduced both behavioural and structural measures of damage by a similar ma...Continue Reading

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Citations

Oct 19, 2016·BBA Clinical·Michael R Hamblin
Jan 13, 2018·Molecular Neurobiology·Farzad SalehpourMichael R Hamblin
Apr 25, 2020·Biomolecules·Farzad Salehpour, Michael R Hamblin
Jun 2, 2020·Translational Neurodegeneration·Luodan YangQuanguang Zhang
Dec 4, 2020·Neural Regeneration Research·Muyue YangZhihui Sun
Jan 21, 2021·Frontiers in Cell and Developmental Biology·Jannik PrasuhnKishore R Kumar
Jan 29, 2021·Chinese Medical Journal·Yu-Lu LiuChun-Feng Liu

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