Near-infrared light-activated red-emitting upconverting nanoplatform for T1 -weighted magnetic resonance imaging and photodynamic therapy

Acta Biomaterialia
Xiang-Long TangWei Xia

Abstract

Photodynamic therapy (PDT) has increasingly become an efficient and attractive cancer treatment modality based on reactive oxygen species (ROS) that can induce tumor death after irradiation with ultraviolet or visible light. Herein, to overcome the limited tissue penetration in traditional PDT, a novel near-infrared (NIR) light-activated NaScF4: 40% Yb, 2% Er@CaF2 upconversion nanoparticle (rUCNP) is successfully designed and synthesized. Chlorin e6, a photosensitizer and a chelating agent for Mn2+, is loaded into human serum albumin (HSA) that further conjugates onto rUCNPs. To increase the ability to target glioma tumor, an acyclic Arg-Gly-Asp peptide (cRGDyK) is linked to rUCNPs@HSA(Ce6-Mn). This nanoplatform enables efficient adsorption and conversion of NIR light (980 nm) into bright red emission (660 nm), which can trigger the photosensitizer Ce6-Mn complex for PDT and T1-weighted magnetic resonance imaging (T1-weighted MRI) for glioma diagnosis. Our in vitro and in vivo experiments demonstrate that NIR light-activated and glioma tumor-targeted PDT can generate large amounts of intracellular ROS that induce U87 cell apoptosis and suppress glioma tumor growth owing to the deep tissue penetration of irradiated light and exc...Continue Reading

Citations

Nov 14, 2019·Chemistry : a European Journal·Shuang ZhaoHongpeng You
Feb 28, 2020·Photochemistry and Photobiology·Elena de Las HerasSanti Nonell
Jan 20, 2019·Journal of Neuro-oncology·K MahmoudiC G Hadjipanayis
Feb 11, 2020·Frontiers in Surgery·Samuel W Cramer, Clark C Chen
Dec 7, 2019·ACS Applied Materials & Interfaces·Renuka KhatikQing Yang

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