Near-Infrared Light-Excited Upconverting Persistent Nanophosphors in Vivo for Imaging-Guided Cell Therapy

ACS Applied Materials & Interfaces
Bin ZhengJin Chang

Abstract

Optical imaging for biological applications is in need of more sensitive tool. Persistent luminescent nanophosphors enable highly sensitive in vivo optical detection and almost completely avoid tissue autofluorescence. Nevertheless, the actual persistent luminescent nanophosphors necessitate ex vivo activation before systemic operation, which severely restricted the use of long-term imaging in vivo. Hence, we introduced a novel generation of optical nanophosphors, based on (Zn2SiO4:Mn):Y3+, Yb3+, Tm3+ upconverting persistent luminescent nanophosphors; these nanophosphors can be excited in vivo through living tissues by highly penetrating near-infrared light. We can trace labeled tumor therapeutic macrophages in vivo after endocytosing these nanophosphors in vitro and follow macrophages biodistribution by a simple whole animal optical detection. These nanophosphors will open novel potentials for cell therapy research and for a variety of applications in diagnosis in vivo.

References

Dec 3, 2002·Science·Benoit DubertretAlbert Libchaber
Jun 21, 2005·Journal of the American College of Cardiology·Yuichi NotomiJames D Thomas
Aug 30, 2005·The American Journal of Pathology·Claire Lewis, Craig Murdoch
Feb 3, 2006·The New England Journal of Medicine·Malik E Juweid, Bruce D Cheson
Mar 8, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Antonio SicaPaola Allavena
Mar 3, 2007·Bulletin of Mathematical Biology·Steven D WebbClaire E Lewis
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Quentin le Masne de ChermontDaniel Scherman
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
May 21, 2010·The Analyst·Feng WangXiaogang Liu
Jan 1, 2009·Immunotherapy·Andreas WeigertBernhard Brüne
Jun 1, 2011·Angewandte Chemie·Markus Haase, Helmut Schäfer
Jun 28, 2011·Journal of the American Chemical Society·Thomas MaldineyDaniel Scherman
Oct 25, 2011·Nature Materials·Feng WangXiaogang Liu
Nov 29, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Zhen HuangJunfeng Zhang
May 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Muthu Kumara Gnanasammandhan JayakumarYong Zhang
Aug 29, 2013·Advanced Materials·Wei FengFuyou Li
Mar 13, 2014·Chemical Reviews·Guanying ChenXiaoyuan Chen
May 23, 2015·Chemical Reviews·Guosong HongHongjie Dai
Sep 22, 2015·Advanced Materials·Si Wu, Hans-Jürgen Butt
Nov 5, 2015·Nature Nanotechnology·Bo ZhouXiaogang Liu
Dec 2, 2015·Advanced Drug Delivery Reviews·Yoshihiro KomoharaMotohiro Takeya
Nov 24, 2016·Theranostics·Thomas LécuyerCyrille Richard
May 12, 2017·ACS Applied Materials & Interfaces·Cong CaoFuyou Li
Jun 21, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Hongbin ChenJin Chang
Sep 1, 2017·ACS Applied Materials & Interfaces·Xiaochen QiuFuyou Li

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Citations

Apr 22, 2021·Journal of Nanobiotechnology·Nian LiuJunpeng Shi
Jan 20, 2021·ACS Biomaterials Science & Engineering·Qianwei ZhuBensheng Qiu
Jan 7, 2022·Chemical Reviews·Bingzhu ZhengXiaogang Liu

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