Near-infrared light increases ATP, extends lifespan and improves mobility in aged Drosophila melanogaster

Biology Letters
Rana BegumGlen Jeffery

Abstract

Ageing is an irreversible cellular decline partly driven by failing mitochondrial integrity. Mitochondria accumulate DNA mutations and reduce ATP production necessary for cellular metabolism. This is associated with inflammation. Near-infrared exposure increases retinal ATP in old mice via cytochrome c oxidase absorption and reduces inflammation. Here, we expose fruitflies daily to 670 nm radiation, revealing elevated ATP and reduced inflammation with age. Critically, there was a significant increase in average lifespan: 100-175% more flies survived into old age following 670 nm exposure and these had significantly improved mobility. This may be a simple route to extending lifespan and improving function in old age.

References

Feb 1, 1970·The Biochemical Journal·M Wilson, C Greenwood
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D Harman
Jun 29, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C E Cooper, R Springett
Oct 7, 2003·Annual Review of Genomics and Human Genetics·Susan E Celniker, Gerald M Rubin
Mar 1, 2005·Cell·Robert S BalabanToren Finkel
Apr 28, 2005·The Journal of Experimental Biology·John R Speakman
Aug 30, 2005·Journal of Photochemistry and Photobiology. B, Biology·Tiina I KaruNatalya I Afanasyeva
Aug 10, 2006·Immunogenetics·Masaru Nonaka, Ayuko Kimura
Apr 7, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vita A VernaceMaria E Figueiredo-Pereira
Sep 25, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yiqiang ZhangHolly Van Remmen
Aug 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ana MesquitaPaula Ludovico
Mar 16, 2013·Reviews in the Neurosciences·Melinda FitzgeraldSarah A Dunlop
Jun 12, 2013·Cell·Carlos López-OtínGuido Kroemer
Mar 19, 2014·Experimental Eye Research·Despoina GkotsiGlen Jeffery

❮ Previous
Next ❯

Citations

Jun 9, 2018·Photochemistry and Photobiology·Michael R HamblinVladimir Heiskanen
Nov 10, 2017·Scientific Reports·Michele M ComerotaGiulio Taglialatela
Dec 19, 2018·Journal of Biophotonics·Qi ZhangMei X Wu
Jul 1, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Harpreet ShinhmarGlen Jeffery

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay
X-ray

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.