Near-infrared light photoacoustic ophthalmoscopy.

Biomedical Optics Express
Tan LiuHao F Zhang

Abstract

We achieved photoacoustic ophthalmoscopy (PAOM) imaging of the retina with near-infrared (NIR) light illumination. A PAOM imaging system with dual-wavelength illumination at 1064 nm and 532 nm was built. We compared in vivo imaging results of both albino and pigmented rat eyes at the two wavelengths. The results show that the bulk optical absorption of the retinal pigment epithelium (RPE) is only slightly higher than that of the retinal vessels at 532 nm while it becomes more than an order of magnitude higher than that of the retinal vessels at 1064 nm. These studies suggest that although visible light illumination is suitable for imaging both the retinal vessels and the RPE, NIR light illumination, being more comfortable to the eye, is better suited for RPE melanin related investigations and diagnoses.

References

Jan 1, 1990·Vision Research·L N ThibosP A Howarth
Jul 11, 2006·Nature Biotechnology·Hao F ZhangLihong V Wang
Aug 1, 2006·Investigative Ophthalmology & Visual Science·Claudia N Keilhauer, François C Delori
Apr 21, 2007·Nature Protocols·Hao F ZhangLihong V Wang
Jul 24, 2006·Optics Express·Jang-Woo YouJohannes F de Boer
Apr 15, 2010·Optics Express·Shuliang JiaoHao F Zhang
Jul 29, 2010·Optics Letters·Song HuLihong V Wang
Jan 25, 2011·Biomedical Optics Express·V M KodachT G van Leeuwen
Feb 18, 2011·Biomedical Optics Express·Jennifer J HunterDavid R Williams
Jul 2, 2011·Progress in Materials Science·Qifa ZhouK Kirk Shung
Aug 3, 2011·Journal of Biomedical Optics·Junjie YaoLihong V Wang
Jan 1, 2011·Journal of Modern Optics·Qing WeiHao F Zhang

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Citations

Oct 18, 2013·Current Eye Research·Tan LiuHao F Zhang
Oct 21, 2016·Photoacoustics·Wenzhong Liu, Hao F Zhang
Apr 23, 2015·Ultrasonic Imaging·Elisabeth Leiss-HolzingerThomas Berer
Dec 12, 2018·Journal of Biological Engineering·Maryse Lapierre-LandryMelissa C Skala
Apr 2, 2015·Optics Letters·Xiaojing LiuShuliang Jiao

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Software Mentioned

PAOM

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