Near-infrared light-sensitive liposomes for enhanced plasmid DNA transfection

Bioengineering & Translational Medicine
Christian WirajaChenjie Xu

Abstract

Near-infrared (NIR) light-responsive liposomes are attractive carriers for targeted and controlled drug delivery to the superficial organ or tissue (e.g., skin). This work describes the development of NIR-responsive liposomes by incorporating gold nanostars within liposomes composed of Phospholipon 90 g and cholesterol. Following cellular delivery, photothermal effect around the gold nanostar upon NIR stimulation induces microcavitation and liposome phase transition which consequently triggers the release of encapsulated molecules. Taking GFP plasmid as an example, we demonstrate enhanced gene transfection into fibroblasts following NIR treatment.

References

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Citations

Dec 6, 2016·Journal of Biomedical Optics·Kathyayini SivasubramanianManojit Pramanik
Apr 11, 2019·Journal of Biomedical Optics·Paul Kumar Upputuri, Manojit Pramanik
Mar 10, 2019·Nature Communications·Christian WirajaChenjie Xu
Jan 4, 2019·Biomedical Engineering Letters·Paul Kumar Upputuri, Manojit Pramanik
Jul 17, 2021·Global Challenges·Pantelitsa DimitriouDavid Barrow
Jul 21, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ahmed RefaatKarlheinz Peter

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Methods Mentioned

BETA
biosensing
transfection
electrophoresis
protein assay
Fluorescence imaging
fluorescence
flow cytometry
Flow

Software Mentioned

ImageJ
SPSS Statistics
FACSDiva

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