Near Infrared Light Sensitive Ultraviolet-Blue Nanophotoswitch for Imaging-Guided "Off-On" Therapy

ACS Nano
Jing ZuoXianggui Kong

Abstract

Photoswitchable materials are important in broad applications. Recently appeared inorganic photoswitchable upconversion nanoparticles (PUCNPs) become a competitive candidate to surmount the widespread issue of the organic counterparts -photobleaching. However, current PUCNPs follow solely Yb3+/Nd3+ cosensitizing mode, which results in complex multilayer doping patterns and imperfectness of switching in UV-blue region. In this work, we have adopted a new strategy to construct Nd3+ free PUCNPs-NaErF4@NaYF4@NaYbF4:0.5%Tm@NaYF4. These PUCNPs demonstrate the superior property of photoswitching. A prominent UV-blue emission from Tm3+ is turned on upon 980 nm excitation, which can be completely turned off by 800 nm light. The quasi-monochromatic red upconversion emission upon 800 nm excitation-a distinct feature of undoping NaErF4 upconversion system-endows the PUCNPs with promising image-guided photoinduced "off-on" therapy in biomedicine. As a proof-of-concept we have demonstrated the imaging-guided photodynamic therapy (PDT) of cancer, where 800 nm excitation turns off the UV-blue emission and leaves the emission at 660 nm for imaging. Once the tumor site is targeted, excitation switching to 980 nm results in UV-blue emission and t...Continue Reading

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Citations

Jan 30, 2019·Methods and Applications in Fluorescence·Blanca Del Rosal, Daniel Jaque
Jul 2, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing ZhaoJun Ou
Oct 13, 2020·Analytical Methods : Advancing Methods and Applications·Hongqi ChenLun Wang
May 1, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jing XiaXiaojun Peng
May 21, 2021·Light, Science & Applications·Yansong FengHong Zhang
Jul 18, 2021·Nature Communications·Qianqian SuDayong Jin
Aug 10, 2019·ACS Applied Materials & Interfaces·Wenbin NiuAlfred Iing Yoong Tok
Sep 28, 2018·Analytical Chemistry·Zhiming ZhangYong Zhang
Oct 22, 2019·Accounts of Chemical Research·Bing Chen, Feng Wang

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