PMID: 2118821Jun 11, 1990Paper

Near-infrared optical responses in feline brain and skeletal muscle tissues during respiratory acid-base imbalance

Brain Research
N B Hampson, C A Piantadosi

Abstract

The effects of hyper- and hypocapnia on oxidative metabolism were evaluated by near-infrared (NIR) multiwavelength spectroscopy in intact brain and skeletal muscle tissues of the anesthetized cat. A 3-wavelength NIR algorithm was used to monitor cytochrome a,a3 oxidation state, regional blood volume, and tissue oxyhemoglobin and O2 stores simultaneously in brain and muscle in ventilated animals. Incremental hypercapnia was produced in 10 cats by raising arterial pCO2 from 27.0 +/- 1.3 to 95.1 +/- 1.9 mmHg with inspired CO2. Hypercapnia produced progressive increases in cerebral HbO2, blood volume, and cytochrome a,a3 oxidation state (P less than 0.01). In contrast, CO2 simultaneously decreased all 3 NIR parameters in intact hindlimb muscles (P less than 0.01). Blood volume changes during hypercapnia correlated with changes in blood flow measured qualitatively by intravascular injections of indocyanine green dye. Hypocapnia produced by hyperventilation in 8 cats lowered paCO2 from 28.5 +/- 0.4 to 13.5 +/- 0.5 mmHg. Hypocapnia decreased cerebral HbO2, blood volume, and cytochrome a,a3 redox level (P less than 0.05), but NIR changes were not seen in skeletal muscle. These experiments demonstrate preferential distribution of oxygen...Continue Reading

References

Mar 1, 1977·Stroke; a Journal of Cerebral Circulation·H A KontosJ L Patterson
Nov 1, 1987·Respiration Physiology·N B HampsonC A Piantadosi
Aug 1, 1986·Critical Care Medicine·C A PiantadosiF F Jöbsis-Vandervliet
Jun 1, 1974·Circulation Research·N A Lassen

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Citations

Jul 17, 1999·Progress in Neurobiology·P L Madsen, N H Secher
Nov 7, 1999·Transplant International : Official Journal of the European Society for Organ Transplantation·T KakefudaS Suzuki
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·T NoriyukiK Dohi
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·S ShibataK Dohi
Feb 6, 2004·Journal of Physiological Anthropology and Applied Human Science·Hisayoshi OgataTokuo Yano
May 23, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yasuhiro FudabaHideki Ohdan
Aug 23, 2008·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Mariko HandaYuzuru Kaneko
Jun 14, 2006·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Michael L WalshYoshiyuki Fukuba
Nov 29, 2002·Anesthesia and Analgesia·Christophe BrouxJean-François Payen

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