Near-Infrared Photoactivatable Immunomodulatory Nanoparticles for Combinational Immunotherapy of Cancer.

Frontiers in Chemistry
Ningyue YuJingchao Li

Abstract

As a promising treatment option for cancer, immunotherapy can eliminate local and distant metastatic tumors and even prevent recurrence through boosting the body's immune system. However, immunotherapy often encounters the issues of limited therapeutic efficacy and severe immune-related adverse events in clinical practices, which should be mainly due to the non-specific accumulations of immunotherapeutic agents. Activatable immunomodulatory agents that are responsive to endogenous stimuli in tumor microenvironment can afford controlled immunotherapeutic actions, while they still face certain extent of off-target activation. Since light has the advantages of noninvasiveness, simple controllability and high spatio-temporal selectivity, therapeutic agents that can be activated by light, particularly near-infrared (NIR) light with minimal phototoxicity and strong tissue penetrating ability have been programmed for cancer treatment. In this mini review, we summarize the recent progress of NIR photoactivatable immunomodulatory nanoparticles for combinational cancer immunotherapy. The rational designs, constructions and working mechanisms of NIR photoactivatable agents are first briefly introduced. The uses of immunomodulatory nanopar...Continue Reading

References

Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Jul 3, 2013·International Journal of Cancer. Journal International Du Cancer·Mei-Ling ChenAnn-Lii Cheng
Oct 24, 2013·Nature Materials·Simona MuraPatrick Couvreur
Mar 11, 2016·Nature Protocols·Muthu Kumara GnanasammandhanYong Zhang
May 5, 2016·Nature Reviews. Clinical Oncology·Celine BoutrosCaroline Robert
Dec 27, 2016·Nature Materials·Rui KuaiJames J Moon
Feb 14, 2017·Journal of the American Chemical Society·Mahdi KarimiMichael R Hamblin
Feb 17, 2018·Molecular Pharmaceutics·Yasuhiro MaruokaHisataka Kobayashi
Feb 21, 2018·Nature Reviews. Clinical Oncology·Joseph C Del Paggio
Aug 4, 2018·Accounts of Chemical Research·Yuyan Jiang, Kanyi Pu
Oct 14, 2018·Advanced Drug Delivery Reviews·Alexandre BordatNicolas Tsapis
May 28, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ni ZhangZhu Yang
Jul 23, 2019·Advanced Drug Delivery Reviews·Joseph M CasterAndrew Z Wang
May 27, 2020·Chemical Society Reviews·Chi Zhang, Kanyi Pu
Jul 17, 2020·Angewandte Chemie·Jingchao LiKanyi Pu

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