Near-infrared spectroscopy-derived lipid core burden index predicts adverse cardiovascular outcome in patients with coronary artery disease during long-term follow-up

European Heart Journal
Anne-Sophie SchuurmanK Martijn Akkerhuis

Abstract

Near-infrared spectroscopy (NIRS) is able to quantify cholesterol within coronary arteries by the lipid core burden index (LCBI). We studied the prognostic value of NIRS-derived LCBI in patients with coronary artery disease (CAD) for adverse cardiac outcome during long-term follow-up. During 2009-2013, NIRS was performed in a non-culprit artery of 275 patients undergoing coronary angiography for acute coronary syndrome (ACS) or stable angina. LCBI was quantified by an independent corelab for the region of interest (LCBIROI) and the 4 and 10 mm long segment with the maximum LCBI (MaxLCBI4mm and MaxLCBI10mm). The primary endpoint was major adverse cardiac events (MACE), defined as the composite of all-cause death, non-fatal ACS, or unplanned revascularization. Hazard ratios (HR) were adjusted for age, gender, clinical risk factors, and segment plaque burden based on intravascular ultrasound. During a median follow-up of 4.1 years, 79 patients (28.7%) had MACE. There was a statistically significant and independent continuous relationship between higher MaxLCBI4mm values and a higher risk of MACE. Each 100 units increase of MaxLCBI4mm was associated with a 19% increase in MACE [hazard ratios (HR) 1.19, 95% confidence intervals (95%...Continue Reading

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Citations

Jun 13, 2018·Journal of Cardiovascular Medicine·Carlo Di MarioFrancesco Rossi
Mar 15, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Konstantinos C KoskinasRobert A Byrne
Mar 15, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Maxime M VroegindeweyMartijn Akkerhuis
Jun 30, 2018·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Cyril ŠtěchovskýJosef Veselka
Mar 9, 2019·Minerva cardioangiologica·Evan ShlofmitzHector M Garcia-Garcia
Jun 8, 2017·European Heart Journal·Carlo Di MarioRon Waksman
Jan 25, 2018·European Heart Journal·Thomas F Lüscher
May 14, 2020·European Heart Journal·Mariusz TomaniakYoshinobu Onuma
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Jul 23, 2020·European Heart Journal Supplements : Journal of the European Society of Cardiology·Martin HorváthJosef Veselka
Jun 26, 2020·Frontiers in Cardiovascular Medicine·James Muller, Ryan Madder
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Dec 2, 2020·Minerva cardioangiologica·Rossella RuggieroSimone Biscaglia

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