Near infrared spectroscopy-guided exercise training for claudication in peripheral arterial disease

European Journal of Preventive Cardiology
Jonathan R MurrowKevin K McCully

Abstract

Supervised treadmill exercise for claudication in peripheral arterial disease is effective but poorly tolerated because of ischemic leg pain. Near infrared spectroscopy allows non-invasive detection of muscle ischemia during exercise, allowing for characterization of tissue perfusion and oxygen utilization during training. We evaluated walking time, muscle blood flow, and muscle mitochondrial capacity in patients with peripheral artery disease after a traditional pain-based walking program and after a muscle oxygen-guided walking program. Patients with peripheral artery disease trained thrice weekly in 40-minute-long sessions for 12 weeks, randomized to oxygen-guided training ( n = 8, age 72 ± 9.7 years, 25% female) versus traditional pain-based training ( n = 10, age 71.6 ± 8.8 years, 20% female). Oxygen-guided training intensity was determined by maintaining a 15% reduction in skeletal muscle oxygenation by near infrared spectroscopy rather than relying on symptoms of pain to determine exercise effort. Pain free and maximal walking times were measured with a 12-minute Gardner treadmill test. Gastrocnemius mitochondrial capacity and blood flow were measured using near infrared spectroscopy. Baseline pain-free walking time was ...Continue Reading

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Citations

Nov 8, 2020·Neuroscience and Biobehavioral Reviews·Keerthana Deepti KarunakaranDavid Borsook
Apr 4, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Nils CornelisVéronique Cornelissen
Jun 11, 2021·Circulation Research·Mary M McDermottLuigi Ferrucci
Jun 10, 2021·European Journal of Applied Physiology·Jon StavresLawrence I Sinoway
May 14, 2021·Journal of Applied Physiology·Pierre-Yves de MüllenheimAlexis Le Faucheur
Aug 27, 2021·Journal of Aging and Physical Activity·Pierre JéhanninPierre-Yves de Müllenheim

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Methods Mentioned

BETA
infrared spectroscopy
biopsies

Software Mentioned

Matlab

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