Near-infrared transillumination imaging combined with aperture photometry for the quantification of melanin in the iris pigment epithelium

PloS One
Maciej Czepita

Abstract

Near-infrared transillumination is used in the diagnosis and the management of different eye diseases. In particular, it enables the visualization of melanin in the pigment epithelium of the iris. This technique is valuable in such conditions as pigment dispersion syndrome and Adie's tonic pupil. Thus, objective quantification of the amount of melanin shedded from the iris pigment epithelium may help in the management of these conditions. By combining aperture photometry with near-infrared iris transillumination this can be achieved. A total of 4 patients (7 eyes) were examined. Three patients were diagnosed with pigment dispersion syndrome in both eyes. One patient had Adie's tonic pupil in one eye. Near-infrared iris transillumination was performed by using a prototype apparatus. Aperture photometry measurements were carried out through specially developed software. The signal-to-noise ratio of the prototype apparatus was 52 dB (399:1). Each pixel within the near-infrared transillumination image corresponded with an area size of the iris of 85 μm x 83 μm. Measurements were taken from several points of the iris in all patients. The average aperture photometry value of transillumination defects was 1321.53 (ADU) ± 501.08 SD, wh...Continue Reading

References

Sep 1, 1979·Archives of Ophthalmology·D G Campbell
Feb 1, 1978·The British Journal of Ophthalmology·M SaariH Nieminen
May 1, 1990·Archives of Ophthalmology·W L AlwardH S Thompson
Jul 1, 1968·American Journal of Ophthalmology·W J Geeraets, E R Berry
Feb 1, 1996·Ophthalmology·J SokolR Ritch
Sep 23, 1998·American Journal of Ophthalmology·M KüchleG O Naumann
Jun 20, 2003·IEEE Transactions on Bio-medical Engineering·R Srinivasan, Megha Singh
Mar 27, 2009·Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye·Daniel K RobertsMiles N Wernick
Nov 1, 1990·Optics Letters·S Andersson-EngelsO Jarlman
Apr 1, 1992·Applied Optics·S A MillerD H Sliney
Mar 5, 2011·Basic & Clinical Pharmacology & Toxicology·Jong-Khing HuangChung-Ren Jan
Apr 25, 2012·Journal of Glaucoma·John H FingertMichael G Anderson
Feb 23, 2019·Sensors·Sabina MerloSara Pizzurro

❮ Previous
Next ❯

Citations

Jun 29, 2021·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Maciej Czepita

❮ Previous
Next ❯

Software Mentioned

ImageJ
APTITI
Aperture Photometry Tool for Infrared Iris Transillumination I...
SharpCap
Aperture Photometry Tool for
Aperture Photometry Tool
Aperture Photometry Tool for Infrared Iris Transillumination I...
JAVA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Lance Lyons, Alec Amram
Transactions of the American Ophthalmological Society
D D Donaldson
Journal français d'ophtalmologie
J M PeroneL Lhuillier
Revue médicale de Liège
A Broens, N Collignon
© 2021 Meta ULC. All rights reserved