Near-Infrared-Triggered in Situ Gelation System for Repeatedly Enhanced Photothermal Brachytherapy with a Single Dose

ACS Nano
Zhouqi MengZhuang Liu

Abstract

Brachytherapy by the placing of therapeutic radioactive materials into or near tumors has been widely used in a clinical setting for cancer treatment. The efficacy of brachytherapy, however, may often be limited by the radiation resistance for tumor cells located in the hypoxic region of a solid tumor as well as the non-optimal distribution of radioactivity inside the tumor. Herein, a hybrid hydrogel system is developed by using 131I-labeled copper sulfide (CuS/131I) nanoparticles as the photothermal- and radiotherapeutic agent, poly(ethylene glycol) double acrylates (PEGDA) as the polymeric matrix, and 2,2'-azobis[2-(2-imidazolin-2-yl) propane] dihydrochloride (AIPH) as the thermal initiator to realize light-induced in situ gelation in the tumor for the combined photothermal brachytherapy. After local injection, CuS/131I nanoparticles under irradiation by the 915 nm near-infrared (NIR) laser would produce heat to mildly raise the tumor temperature and initiate the polymerization of PEGDA by activating the AIPH thermal initiator, effectively fixing CuS/131I by in situ gelation within the tumor for the long term. By the repeated NIR irradiation of tumors, the tumor hypoxia could be relieved for a much-longer term, resulting in a...Continue Reading

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Citations

Jan 23, 2020·Nanoscale·Lirong ZhaoXianwei Meng
May 23, 2020·Bioengineering & Translational Medicine·Abhirup MandalSamir Mitragotri
Nov 27, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Juan LuPiaoping Yang
Feb 12, 2021·Accounts of Chemical Research·Xia Wang, Qigang Wang
Feb 16, 2021·ACS Applied Materials & Interfaces·Amit NainHuan-Tsung Chang
Mar 30, 2021·Bioconjugate Chemistry·Yijing ZhangJuan Diwu
Apr 21, 2021·Macromolecular Rapid Communications·Chunxiang MoYuping Chen
Nov 2, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaokang JinBing Wang
Jan 13, 2022·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jieyao ChenYue Pan

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