Abstract
Tetraploidy and near-tetraploidy are observed infrequently in hematologic malignancies, most commonly seen in cases of childhood acute lymphoblastic leukemia, and are associated with large blast size. Four cases of adult acute myelogenous leukemia (AML) with tetraploid or near-tetra-ploid karyotypes are reported, along with review of the related literature. AML subtypes included M1, M1, M4, and M5b. Tetraploidy was determined cytogenetically and confirmed by image cytometry (DNA index 2.0). The subjective impression of large blast size was confirmed by image cytometry, demonstrating mean blast nuclear areas of 237, 177, 203, and 216 microns2, (mean 208 microns2) in the cases with tetraploidy, compared to a mean of 134 microns2 in 10 control cases of AML with diploid or near diploid chromosome patterns. The clinical course was variable in the four cases reported. When compared with previously published cases, the occurrence of tetraploidy or near-tetraploidy in adult AML, unlike childhood ALL, does not appear to define a distinct subgroup in terms of FAB classification or to carry prognostic implications.
References
Aug 1, 1976·British Journal of Haematology·J M BennettC Sultan
Feb 1, 1979·Australian and New Zealand Journal of Medicine·A Manoharan, M J Leyden
Dec 1, 1991·Cancer Genetics and Cytogenetics·M E ShererS M Gollin
Feb 16, 1991·The Veterinary Record·R A Hillam
Nov 1, 1988·Cancer Genetics and Cytogenetics·L ZelanteB Dallapiccola
Jul 15, 1988·Cancer Genetics and Cytogenetics·H HarthH Zankl
Jan 1, 1985·Cancer Genetics and Cytogenetics·R AbeA A Sandberg
Jun 1, 1985·Cancer Genetics and Cytogenetics·M J Kocova, A A Sandberg
Oct 1, 1985·Annals of Internal Medicine·J M BennettC Sultan
Mar 1, 1980·British Journal of Haematology·S D LawlerT J McElwain
Jul 1, 1994·Leukemia Research·P LemezJ Hrabánek
Mar 1, 1993·Leukemia & Lymphoma·H Preisler
Feb 1, 1994·Cancer Genetics and Cytogenetics·Y L KwongL C Chan
Jan 1, 1993·British Journal of Haematology·A P GriggD E Horsman
Jun 2, 1993·Journal of the National Cancer Institute·B K IrelandL D Kier
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M M Le BeauC A Westbrook
Citations
Feb 15, 2002·International Journal of Hematology·Hiroki YamaguchiKazuo Dan
Nov 28, 2001·International Journal of Hematology·K YamamotoH Hamaguchi
Oct 12, 2012·International Journal of Hematology·Li LiHongwei Wang
Mar 26, 2004·Cancer Genetics and Cytogenetics·Alessandro GozzettiFrancesco Lauria
Jul 29, 1998·Leukemia Research·P LemezJ Jelínek
Aug 24, 1999·Leukemia Research·L OlcayA M Tuncer
Jul 30, 2003·Cancer Genetics and Cytogenetics·Seung Hwan OhGoon Jae Cho
Dec 31, 2003·Cancer Genetics and Cytogenetics·Renuka V IyerMaria R Baer
Apr 8, 1998·Cancer Genetics and Cytogenetics·W Y AuY L Kwong
Apr 18, 1998·Cancer Genetics and Cytogenetics·B EspinetJ Sans-Sabrafen
Nov 24, 1999·Cancer Genetics and Cytogenetics·W Y AuY L Kwong
Mar 16, 2002·Journal of Clinical Pathology·R NounouM Gyger
Jun 29, 2004·International Journal of Hematology·Jun KuyamaTatsuo Matsuyama
Feb 19, 2005·International Journal of Hematology·Ken KaitoMasayuki Kobayashi
Jun 14, 2015·American Journal of Clinical Pathology·James Vardiman, Kaaren Reichard
Jun 20, 2015·American Journal of Hematology·Vladimir LazarevicBertil Johansson
Dec 9, 2008·Cancer Genetics and Cytogenetics·Jinlan PanJuan Shen
Jan 8, 2015·Journal of Clinical Pathology·Changlee S PangTimothy S Pardee
Dec 6, 2011·Leukemia Research·Sanjeev Kumar SharmaRenu Saxena
Jan 28, 1999·Leukemia & Lymphoma·S S KaplanS Shekhter-Levin
Aug 16, 2016·Journal of Clinical Pathology·Atsushi WatanabeKanji Sugita
Feb 12, 2008·Cancer Genetics and Cytogenetics·Daniela BettioBarbara Sarina
Jun 28, 2011·Acta Haematologica·Petr LemežJaroslav Jelínek
Oct 10, 2009·Journal of Pediatric Hematology/oncology·Ji-Hong ZhangZhuo-Gang Liu
Oct 1, 2020·Leukemia & Lymphoma·John XieHana Safah
Dec 1, 2017·Cancers·Eigil Kjeldsen
Mar 27, 2004·Archives of Pathology & Laboratory Medicine·Marwa ImkieMark T Cunningham