Near-tetraploidy in adult acute myelogenous leukemia

Cancer Genetics and Cytogenetics
M R ClarkeS Shekhter-Levin

Abstract

Tetraploidy and near-tetraploidy are observed infrequently in hematologic malignancies, most commonly seen in cases of childhood acute lymphoblastic leukemia, and are associated with large blast size. Four cases of adult acute myelogenous leukemia (AML) with tetraploid or near-tetra-ploid karyotypes are reported, along with review of the related literature. AML subtypes included M1, M1, M4, and M5b. Tetraploidy was determined cytogenetically and confirmed by image cytometry (DNA index 2.0). The subjective impression of large blast size was confirmed by image cytometry, demonstrating mean blast nuclear areas of 237, 177, 203, and 216 microns2, (mean 208 microns2) in the cases with tetraploidy, compared to a mean of 134 microns2 in 10 control cases of AML with diploid or near diploid chromosome patterns. The clinical course was variable in the four cases reported. When compared with previously published cases, the occurrence of tetraploidy or near-tetraploidy in adult AML, unlike childhood ALL, does not appear to define a distinct subgroup in terms of FAB classification or to carry prognostic implications.

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Citations

Feb 15, 2002·International Journal of Hematology·Hiroki YamaguchiKazuo Dan
Mar 26, 2004·Cancer Genetics and Cytogenetics·Alessandro GozzettiFrancesco Lauria
Dec 31, 2003·Cancer Genetics and Cytogenetics·Renuka V IyerMaria R Baer
Apr 18, 1998·Cancer Genetics and Cytogenetics·B EspinetJ Sans-Sabrafen
Nov 24, 1999·Cancer Genetics and Cytogenetics·W Y AuY L Kwong
Feb 19, 2005·International Journal of Hematology·Ken KaitoMasayuki Kobayashi
Jun 14, 2015·American Journal of Clinical Pathology·James Vardiman, Kaaren Reichard
Jun 20, 2015·American Journal of Hematology·Vladimir LazarevicBertil Johansson
Dec 9, 2008·Cancer Genetics and Cytogenetics·Jinlan PanJuan Shen
Jan 8, 2015·Journal of Clinical Pathology·Changlee S PangTimothy S Pardee
Dec 6, 2011·Leukemia Research·Sanjeev Kumar SharmaRenu Saxena
Jan 28, 1999·Leukemia & Lymphoma·S S KaplanS Shekhter-Levin
Aug 16, 2016·Journal of Clinical Pathology·Atsushi WatanabeKanji Sugita
Mar 27, 2004·Archives of Pathology & Laboratory Medicine·Marwa ImkieMark T Cunningham

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