Near tetraploidy in three cases of acute myeloid leukemia associated with mediastinal granulocytic sarcoma

Cancer Genetics and Cytogenetics
W Y AuY L Kwong

Abstract

Granulocytic sarcoma (GS) is a rare manifestation of acute myeloid leukemia (AML), blastic transformation of chronic myeloid leukemia, and the myelodysplastic syndromes. The mediastinum is an unusual site of presentation. We report a series of three female patients with mediastinal GS. They were characterized by the presence of large and bizarre blast cells and near tetraploidy on cytogenetic analysis. All three patients responded poorly to chemotherapy. Near tetraploid AML is a rare entity, usually present in male patients, and has not been associated with GS. The clinical and pathological similarities in these three cases suggest a distinct category of poor-risk AML for which more intensive treatment is needed.

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Citations

Feb 15, 2002·International Journal of Hematology·Hiroki YamaguchiKazuo Dan
Dec 31, 2003·Cancer Genetics and Cytogenetics·Renuka V IyerMaria R Baer
Nov 24, 1999·Cancer Genetics and Cytogenetics·W Y AuY L Kwong
Apr 16, 2014·Leukemia & Lymphoma·Mariella D'angiòAnna Maria Testi
Jun 20, 2015·American Journal of Hematology·Vladimir LazarevicBertil Johansson
Jan 21, 2000·Experimental and Molecular Pathology·H F MarkP Rintels
Jan 8, 2015·Journal of Clinical Pathology·Changlee S PangTimothy S Pardee
Dec 29, 1999·Leukemia & Lymphoma·W Y AuR Liang
Oct 26, 2005·Bone Marrow Transplantation·M GorschlüterI G H Schmidt-Wolf

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