Nearly uniform failure of atrial flutter ablation and continuation of antiarrhythmic agents (hybrid therapy) for the long-term control of atrial fibrillation.

Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing
Nicholas AnastasioDavid J Callans

Abstract

Ablation for atrial flutter and continued pharmacologic therapy (hybrid therapy) is a management strategy when treatment with class I antiarrhythmic drugs organize atrial fibrillation (AF) into flutter. Previous studies with 2-3-year follow-up have reported satisfactory control of AF burden. We evaluated the effectiveness of hybrid therapy after a follow-up of 5 years. We hypothesized that longer term follow-up would demonstrate eventual failure of this strategy to control AF. A consecutive, retrospective evaluation of all first time ablations of right atrial flutter at the University of Pennsylvania between August 2003 and August 2005 was performed (n = 179). The study population consisted of 33 patients who had atrial flutter only after treatment of AF with class I antiarrhythmic drugs and was continued on them post-ablation. Follow-up data were obtained by reviewing records from our institution, from referring cardiologists, and from direct patient questionnaires. Atrial fibrillation recurrence was noted in 28 of 31 patients (90.3 %) who completed 5 years of follow-up. AF recurrence typically resulted in significant symptoms, although 21 % developed persistent AF and were eventually minimally symptomatic on a rate control st...Continue Reading

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Citations

Aug 8, 2012·Health and Quality of Life Outcomes·Javier García SearaJosé R González Juanatey
Oct 30, 2012·Clinics in Geriatric Medicine·Jane Chen
Mar 25, 2014·Journal of Cardiovascular Electrophysiology·Béatrice Brembilla-PerrotArnaud Terrier DE LA Chaise
Apr 26, 2014·Journal of Cardiovascular Electrophysiology·Tomos E Walters, Jonathan M Kalman
Mar 31, 2016·Clinical Cardiology·Víctor ExpósitoJuan J Olalla
Jul 22, 2014·International Journal of Cardiology·Javier García SearaJosé Ramón González Juanatey
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Nov 4, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Paulus KirchhofKatja Zeppenfeld
Sep 25, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Paulus KirchhofKatja Zeppenfeld

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