NEAT1/hsa-mir-98-5p/MAPK6 axis is involved in non-small-cell lung cancer development

Journal of Cellular Biochemistry
Feima WuHai-Bo Hu

Abstract

Long noncoding RNAs (lncRNAs) or microRNAs belong to the two most important noncoding RNAs and they are involved in a lot of cancers, including non-small-cell lung cancer (NSCLC). Therefore, currently, we focused on the biological and clinical significance of lncRNA nuclear enriched abundant transcript 1 (NEAT1) and hsa-mir-98-5p in NSCLC. It was observed that NEAT1 was upregulated while hsa-mir-98-5p was downregulated respectively in NSCLC cell lines compared to human normal lung epithelial BES-2B cells. Inhibition of NEAT1 can suppress the progression of NSCLC cells and hsa-mir-98-5p can reverse this phenomenon. Bioinformatics search was used to elucidate the correlation between NEAT1 and hsa-mir-98-5p. Additionally, a novel messenger RNA target of hsa-mir-98-5p, mitogen-activated protein kinase 6 (MAPK6), was predicted. Overexpression and knockdown studies were conducted to verify whether NEAT1 exhibits its biological functions through regulating hsa-mir-98-5p and MAPK6 in vitro. NEAT1 was able to increase MAPK6 expression and hsa-mir-98-5p mimics can inhibit MAPK6 via downregulating NEAT1 levels. We speculated that NEAT1 may act as a competing endogenous lncRNA to upregulate MAPK6 by attaching hsa-mir-98-5p in lung cancers....Continue Reading

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Citations

Apr 2, 2019·Journal of Cellular Physiology·Li-Yun YuanHui Xing
Mar 30, 2019·Cancer Chemotherapy and Pharmacology·Shian LiaoYanhui Ma
Oct 3, 2018·International Journal of Oncology·Wei SunDongsheng Huang
Sep 27, 2019·Experimental and Therapeutic Medicine·Feng ZhengZhe Xu
Feb 6, 2019·International Journal of Molecular Sciences·Felix PrinzChristiane Klec
Aug 30, 2019·Cancer Cell International·Fei DingShumao Zheng
Jan 9, 2019·Journal of Cellular Biochemistry·Zhuoxing LiuAibing Wu
Nov 16, 2018·Molecular Oncology·Christiane KlecMartin Pichler
Jun 21, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yufu TangXiaoge Wang
Nov 5, 2020·Non-coding RNA·Gabriel Pisani, Byron Baron
Dec 18, 2020·Cancer Cell International·Rong-Hang HuShao-Qiang Wang
Mar 19, 2021·The Journal of International Medical Research·Hongxia Wu, Aiwen Liu
May 29, 2021·Environmental Science and Pollution Research International·Marwa M MahmoudNadia M Hamdy
Jan 22, 2022·Expert Opinion on Therapeutic Targets·Robert Walters, Shaker A Mousa

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