Nebivolol to attenuate the effects of hyper-homocysteinaemia in rats

Atherosclerosis
Cagdas AkgulluHasan Güngör

Abstract

This study investigated the prophylactic effect of nebivolol against hyper-homocysteinaemia (hHcy) induced oxidative stress in brain, heart, liver and kidney tissues and histomorphometric changes in the thoracic aorta. Twenty-four adult male Wistar rats were divided into a control, nebivolol, hHcy and nebivolol+hHcy group. hHcy was induced by oral administration of L-methionine (1 g/kg/day) for 28 days. 10 mg/kg/day nebivolol was administered orally for 28 days. Malondialdehyde (MDA) and glutathione (GSH) levels and catalase (CAT) and superoxide dismutase (SOD) activities in the tissues were determined. The total cross-sectional area (TCSA), luminal cross-sectional area (LCSA) and intima-media thickness (IMT) were measured in the thoracic aorta. Homocysteine (Hcy) levels were lower in the nebivolol+hHcy group than in the hHcy group. Nebivolol treatment significantly decreased high MDA levels in the brain, heart and liver tissues. The level of GSH was higher in the brain, heart and kidney tissues of the nebivolol+hHcy group (P<0.001). The activity of CAT increased only in the kidney tissue of the nebivolol+hHcy group (P<0.01), and the activity of SOD was significantly increased in all the tissues in this group. Increased TCSA an...Continue Reading

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Citations

Dec 1, 2015·Basic & Clinical Pharmacology & Toxicology·Mohamed A Morsy, Gehan H Heeba
Mar 7, 2018·Clinical and Experimental Pharmacology & Physiology·Jovana JeremicVladimir Jakovljevic
Jan 5, 2018·Nutrition & Metabolism·Avinash KumarSubramanyam N Murthy
Sep 7, 2018·Journal of Cardiovascular Pharmacology·Alexander Vladimirovich IvanovAslan Amirkhanovich Kubatiev
May 21, 2017·Inflammation·Liu JingyanMiao Mingxing
Jun 15, 2021·Saudi Journal of Biological Sciences·Atefeh RahimiSaied Karbalay-Doust

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